PBX蛋白促肿瘤转移及VCP表达的调节作用研究
基本信息
结项摘要
本项目拟探索的PBX（Pre B-cell leukemia transcription factor）蛋白是具有高度保守的同源结构域的蛋白家族，其主要成员PBX1、PBX2是被证实作为多种蛋白的共因子，调节蛋白的功能。申请者在自身原有研究发现的基础上，拟通过构建不同的PBX蛋白表达的细胞模型，深入探讨PBXs蛋白在肿瘤转移与促进VCP（Valosin-Containing Protein）表达过程中的PBXs-VCP信号通路以及在特定的细胞周期中的蛋白调节机制；并利用临床肿瘤手术标本进一步探讨PBXs蛋白表达与肿瘤患者预后的关系；采用生物芯片技术筛查PBX调控的主要靶蛋白，探讨PBX与靶蛋白的相互作用及其与肿瘤转移的相关信号调节模式。这对于探讨肿瘤转移的新的信号机制，寻找抗肿瘤治疗的新靶点，建立针对该特定途径的抑制肿瘤转移的方法，提高临床肿瘤患者的生存具有重要的理论意义和潜在的应用价值
项目摘要
项目成果
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数据更新时间：2023-05-31
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