生物超分子功能的电分析化学研究

This project focused on the electrochemical study of functional suparmolecules using supramolecular interactions and multi-subject methods. Many original results have been achieved. It is as follows: the fabrication of a series of novel biomimic interfaces, the synthesis of all kinds of shapes of functional nanomaterials, the preparation of three-demensional ordered films, the establishment of chiral separation model of anion-cyclodextrin electrokinetic chromatography and induced cleavage of.DNA by electrochemical methods, the immobilization of enzymes with sol-gel.methods, the preparation of carbon nanotube modified electrodes,fullerene-cyclodextrin and e-calixarene supramolecules modified ,fullerene-DDAB film modified electrodes, elf-assembled monolayer of iomoleculesmodified odes, the study of interaction mechanism between DNA, protein and drugs and electrochemical and ourescent detection of DNA, protein,antigen/antibody, and other important biomolecules.

针对生物超分子功能的研究方法，建立蛋白质、酶、核酸等生物大分子的直接电分析方法；利用功能分子自组、纳米和生化技术构筑具有分子识别功能的检测器件与探针，研究生物超分子的形成、结构与电化学行为的关系，研究微量金属对酶活性的影响和酶催化机理，发展生物分子电催化，建立新型的理论体系，发展电化学分析，为四化建设和科学进步作贡献。