可降解材料在发育期动物颅骨缺损修复中的研究

Skull repair in young children with rapid skull growth is a difficult problem for neurosurgeons in clinical. Our previous studies have demonstrated the characteristics of the development of the growth the skull slowed year by year after the most rapid period of skull growth occurred during the first year of life and demonstrated that skull defect edge grew inward and reduced the cranial bone window gradually. Overlay repair may limit the skull development and filling undegradable material type repair may lead to conflict between cranial bone window edge and repair material .These may cause skull malformations. The children will take the risk of lack of the skull to protect brain tissue from injury long time if the repair operation were do when they are old enough. Therefore, it is very important to choose an appropriate degradable material to repair young children skull defects. The aim of this study was to detect the degradation, repair materials for skull defects induced by edge osteogenesis process , rate matching relationship and the interface between repair material and new bone in young sheep skull defect model using a kind of degradable mineralized collagen artificial bone repair material,with good osteogenetic activity(including magnesium alloy stent mineralized collagen repair materials), The osteogenic properties and clinical application value will be evaluated at organization, cell and molecular, levels. The value of mineralized collagen artificial materials will be discussed in children skull repair. This study will give some clues or inspirations to doctor to repair children skull. This study want to prove this biological material for repairing skull in children just like nature bone repair materials also.

小儿颅骨缺损修复一直是临床上的难点。我们研究已证实，发育期颅骨呈现先快后慢的生长特点，且颅骨缺损边缘向内生长，骨窗逐渐缩小。覆盖式修复可能限制颅骨发育；非降解材料填充修复可能致骨窗边缘与修复材料的对抗，均可致颅骨发育畸形，如颅骨成熟后再行修复，存在长时间的旷置风险，缺乏颅骨保护的脑组织极易受到损伤。因此选择合适的可降解材料对小儿颅骨缺损修复有重要的临床意义。本课题拟利用发育期幼羊颅骨缺损模型，使用具良好成骨活性的可降解矿化胶原人工骨修复材料（包括含镁合金支架材料），探讨修复材料在发育期颅骨的降解、诱导颅骨缺损边缘成骨过程及其速率匹配关系、材料-骨组织界面结合等颅骨修复过程中的关键科学问题，从组织、细胞和分子等层次研究新生骨结构并评价矿化胶原人工材料成骨性能和临床应用价值，揭示其应用于小儿颅骨缺损修补潜在价值，指导小儿颅骨缺损修复，探寻一项符合生物学的颅骨修复材料，实现真正的骨修复。

小儿颅骨缺损修复一直是临床上的难点。我们研究已证实，发育期颅骨呈现先快后慢的生长特点，且颅骨缺损边缘向内生长，骨窗逐渐缩小。覆盖式修复可能限制颅骨发育；非降解材料填充修复可能致骨窗边缘与修复材料的对抗，均可致颅骨发育畸形，如颅骨成熟后再行修复，存在长时间的旷置风险，缺乏颅骨保护的脑组织极易受到损伤。因此选择合适的可降解材料对小儿颅骨缺损修复有重要的临床意义。本课题拟利用发育期幼羊颅骨缺损模型，使用具良好成骨活性的可降解矿化胶原人工骨修复材料（包括含镁合金支架材料），探讨修复材料在发育期颅骨的降解、诱导颅骨缺损边缘成骨过程及其速率匹配关系、材料-骨组织界面结合等颅骨修复过程中的关键科学问题，从组织、细胞和分子等层次研究新生骨结构并评价矿化胶原人工材料成骨性能和临床应用价值，揭示其应用于小儿颅骨缺损修补潜在价值，指导小儿颅骨缺损修复，探寻一项符合生物学的颅骨修复材料，实现真正的骨修复。