基于有机Pt(II)配位的两亲性金属大环/笼的超分子自组装研究

Amphiphilic supramolecular self-assembly is the process that amphiphilic building blocks form well-defind structures driven by various weak interactions (van der Waals' force, hydrogen bond, aromatic stacking, host-guest interaction, charge transfer interaction etc). In recent years, although supramolecular self-assembly properties of numerous (traditional linear amphiphilies, macrocyclic amphiphilies, supramolecular amphiphilies etc) synthetic amphiphilic compounds have been investigated and reported, the study about amphiphilic metallacycles or metallacages is just started. The aim of this project is to study on design and syntheses amphiphilic discrete organoplatinum(II) metallacompounds with different functional groups and different dimensionalities. Combined the charge transfer interaction from coordination bond, host-guest molecular recognition from the cavity and the hydrophilic-hydrophobic interaction from the amphiphilic nature, these amphiphilic discrete organoplatinum(II) metallacycles/cages can self-assembly into various well-defined and controllable micro materials. These materials can be widely applied in photo catalysis, controllable drug delivery, photodynamics therapy etc, leading to the development of supramolecular self-assembly and novel nanomaterials.

两亲超分子自组装是指两亲性的构筑基元在弱相互作用力（范德华力、氢键、芳香堆积、主客体作用、电荷转移等）的诱导下自发地形成具有规整结构体系的过程。近些年，已有许多关于两亲化合物（包括传统线性两亲化合物，大环两亲化合物以及超两亲化合物）超分子自组装的研究与报道，但关于金属配位的两亲大环、笼状化合物的研究才刚刚起步。本项目致力于设计与合成具有不同维度、不同官能团的两亲性有机Pt(II)配位的金属大环/笼。结合此类化合物中配位键之间电荷转移所引起的性质调控、大环/笼空腔所具有的主客体分子识别作用以及两亲化合物优越的自组装性质，通过超分子自组装制备一系列形貌规整，性质可控的微观材料，并将这些材料应用与光动力催化、药物的控制释放、光动力治疗等领域，推动超分子自组装和纳米新材料的发展。

本项目通过设计与合成具有不同维度、不同官能团的两亲性有机Pt(II)配位的金属大环/笼，主要以吡啶卟啉或者吡啶四苯乙烯为核，以甘醇链修饰的间苯二甲酸为亲水基元，结合此类化合物中配位键之间电荷转移所引起的性质调控、大环/笼空腔所具有的主客体分子识别作用以及两亲化合物优越的自组装性质，通过超分子自组装制备一系列形貌规整，性质可控的微观纳米材料材料，并将这些材料应用与光动力催化、药物的控制释放、肿瘤的光动力治疗等领域，将基础研究核实际应用结合，为推动超分子自组装和纳米新材料的发展奠定基础。