非侵入眼内压连续监测的关键技术与系统研究

The Intraocular Pressure(IOP) is balanced pressure that ocular contents is applied to the eye wall. IOP stablizing in a certain range is mainly to maintain the form and normal physiological function of eyeball. A variety of ophthalmology diseases and others, including ophthalmology operation, etc, will be accompanied by the Intraocular Pressure fluctuations.Glaucoma is already recognized as the second blind disease by the World Health Organization. It is believed that the rise and fluctuation of Intraocular Pressure are the most dangerous factors to occurrence, development and blind of glaucoma. Therefore, it is significantly important to establish a relationship-model between fluctuations of Intraocular Pressure and micro-deformations of eyeball, especially for non-wounded and continuous monitoring in Intraocular Pressure fluctuations. The aim of studying this project is to explore the relationship between Intraocular Pressure changes and eyeball surface transformation and construct micro-deformation model of eyeball surface, which can provide reliable scientific basis for non-intrusive and continuous monitor to Intraocular Pressure. A new non-intrusive method to achieve Intraocular Pressure monitoring through micro sensing system has been put forward.Study and establish a system of micro-sensors for non-intrusive,non-wounded and IOP continuous monitoring.

眼内压是眼内容物对眼球壁施加的均衡压力, 其稳定在一定范围内，以维持眼球的正常形态和正常生理功能，多种眼科疾病都会伴随着眼内压的波动变化。青光眼是世界卫生组织公认的第二大致盲眼科疾病，眼内压升高和波动增大是青光眼发生、发展、致盲的最危险因素，非侵入无创的连续眼内压监测对于青光眼诊断和治疗具有重要意义。本项目围绕无创连续眼内压测量目的，研究探索眼内压变化引起眼球表面变形的关系理论，建立眼球变形与眼压关系理论模型，提出一种基于容栅形变传感和磁耦合无线传输的无创连续的眼内压监测新方法，研究建立眼内压无创连续测量的微传感系统。

非侵入无创的连续眼内压监测对于青光眼诊断和治疗具有重要意义。本项目围绕无创连续眼内压测量目的，研究探索眼内压变化引起眼球表面变形的关系理论，建立眼球变形与眼压关系理论模型，提出一种基于容栅形变传感和磁耦合无线传输的无创连续的眼内压监测新方法，研究建立眼内压无创连续测量的微传感系统。通过对项目计划的执行，项目研究基本达到了预期的目标。项目发展了更好的基于微流体原理的眼压监测隐形眼镜研究，并完成了含有微通道的隐形眼镜制造工艺研究，搭建了检测系统样机，获得了重要的研究成果。项目发表SCI论文4篇，申请发明专利7项，授权3项，参加国际会议4次，宣读论文3次。该项目的研究极大的提高了我国在非侵入眼压连续检测领域的国际地位，为临床解决连续眼压检测问题提供了切实可行的思路和方法。