珠江三角洲妇婴人群中有机紫外防护剂和人工合成香料暴露水平及生殖健康影响初探

Backgroud: Risk associated with previously unrecognized or unsuspected chemical pollutants in the environment has long been a major concern of environmental scientists. It is quite critical to protect ecologic and human health by identifying and investigating the potential environmental pollution issues before they worsen. During the last decades, the impact of chemical pollution has focused exclusively on the conventional "priority" pollutants, which would only be one piece of the large puzzle in "holistic" risk assessment. Nowadays, the pharmaceuticals and active ingredients in personal care products (PPCPs) receives comparatively little but increasing attention due to their large amount of usage throughout the world as well as the comparable quantities introduced into the environment with "priority" pollutants. UV filters and polycyclic musks just belong to this class of chemicals. Some of UV filters and musks have shown potential endocrine disruption properties and additive effect could be found for multi-exposure. Studies on the exposure level of those compounds in environment as well as their impact on reproductive function were only performed in few countries, which become the driving force for us to start this proposal in China. .Objective: Three parts of work would be done to clarify the exposure level of UV filters and polycyclic musks in urban aquatic environment in Pearl River Delta Area and assess their impact on reproductive function within women and embryos or neonates in this region. .Proposal in brief: 1) Accurate, precise and convenient analytical methods would be established for different type of environmental and biological samples. 2)Exposure level of UV filters and Polycyclic musks in urban aquatic environment in Pearl Delta Area would be investigated by determining their concentration in different components of aquatic environment, such as water, sediment, sludge, biota, etc. The investigation results would be used for their environmental and health risk assessment. 3)The impact on reproductive function would be conducted by the following means. Firstly, the concentrations of these two types of compounds in specimens of normal women, women suffering from endocrine-related diseases and women having adverse pregnancy history would be measured. Secondly, statistic analysis would be performed to find the correlation between diseases and exposure to these two types of compounds using survey/questionnaire data (such as data on personal lifestyle, product use, and food consumption etc.), together with data of exposure level investigation. Thirdly, transmission of UV filters and musks from mothers to offsprings were investigated to assess their impact on offsprings health by analyzing their concentrations in related biological samples (breast milk, placental blood and umbilical blood, etc.) and correlation analysis.

通过对珠江三角洲城市水体及水产品、禽肉产品中有机紫外防护剂和人工合成香料的检测及结果分析，探索两类化合物在该地区城市水体和水产品、禽肉产品中的污染程度，分析赋存形态、含量结构，评估该地区人群污染物的饮水、膳食暴露水平。同时，通过调查患有内分泌相关疾病及不良孕产史女性的地域分布、生活习性等信息，检测其各个组织中两类化合物浓度，并结合暴露水平结果及问卷调查进行相关性分析，寻找污染物与疾病的联系，同时系统分析该两类化合物对人体内性激素合成过程及下丘脑-脑垂体-性腺轴（HPGA）的影响，揭示其对生殖内分泌的毒理效应，评估这两类物质对女性生殖健康的影响；此外，通过采集妊娠、哺乳期母婴血液、乳汁等生物样品，对其进行两类化合物含量检测，分析不同化合物自母及婴的传递特性。通过该项目的研究，有望为今后污染物风险评价模型的建立和运行及污染物控制措施的制定提供数据基础。

本项目拟通过对珠江三角洲城市水体及水产品中有机紫外防护剂和人工合成香料的检测及结果分析，探索两类化合物在该地区城市水体和水产品中的污染程度，分析赋存形态、含量结构，评估人群水环境可能暴露水平。同时，通过调查，结合水环境暴露水平结果相关性分析，研究疾病与目标化合物关系，评估这两类物质对人类健康的影响。项目基本完成计划，建立了一系列针对不同类型样品的分析方法，利用不同的前处理方法及仪器分析方法，可准确可靠地分析不同基质样品目标化合物；研究了珠江河口和南中国海目标化合物赋存形态及生物体中含量结构，了解珠江三角洲河口及近海水环境现状；研究了大气环境目标化合物含量结构情况，了解大气环境目标化合物污染现状，进行呼吸病患胸水目标化合物含量调查，初步了解目标化合物与疾病关系；研究普通人群血尿中目标化合物含量特征，进行胚胎停育病患血液目标化合物含量调查，初步研究疾病与目标化合物相互关系。项目执行过程发表了系列相关文章，培养多名研究生。