维生素D3通过表皮生长因子受体抑制卵巢癌信号转导通路的研究
基本信息
结项摘要
1,25二羟基维生素D3（1,25VD3）及其类似物是很有前途的治疗卵巢癌的新药。前期工作证实1,25VD3对卵巢癌细胞有强烈生长抑制作用，其作用机理包括调节P27、GADD45蛋白，阻断细胞周期G1/S、G2/M期转换，但具体分子机制仍不是很清楚。我们进一步实验显示，1,25VD3下调EGFR在生长抑制中具有关键的作用。本课题目的是为了阐明1,25VD3通过EGFR抑制卵巢癌细胞的信号通路，明确
项目摘要
项目成果
{{i.achievement_title}}
{{i.achievement_title}}
暂无此项成果
数据更新时间：2023-05-31
其他相关文献
Influencing factors of carbon emissions in transportation industry based on CD function and LMDI decomposition model: China as an example
Influencing factors of carbon emissions in transportation industry based on CD function and LMDI decomposition model: China as an example
The Role of Osteokines in Sarcopenia: Therapeutic Directions and Application Prospects
The Role of Osteokines in Sarcopenia: Therapeutic Directions and Application Prospects
Combining Spectral Unmixing and 3D/2D Dense Networks with Early-Exiting Strategy for Hyperspectral Image Classification
Combining Spectral Unmixing and 3D/2D Dense Networks with Early-Exiting Strategy for Hyperspectral Image Classification
TGF-β1-Smad2/3信号转导通路在百草枯中毒致肺纤维化中的作用
TGF-β1-Smad2/3信号转导通路在百草枯中毒致肺纤维化中的作用
Facile Fabrication of Hollow Hydrogel Microfiber via 3D Printing-Assisted Microfluidics and Its Application as a Biomimetic Blood Capillary
Facile Fabrication of Hollow Hydrogel Microfiber via 3D Printing-Assisted Microfluidics and Its Application as a Biomimetic Blood Capillary
张晓晖的其他基金
相似国自然基金
卵巢癌细胞中血小板活化因子受体与表皮生长因子受体信号通路串话研究
活性维生素D3通过VDR调控SOCS和JAK／STAT通路在糖尿病肾病中的作用研究
维生素D3调节人骨肉瘤细胞系增殖分化的信号转导机制
支气管哮喘中维生素D3通过T-bet通路调控ILC2s功能的机制研究