细胞间质中组织液定向流动研究

Interstitial fluid is the surroundings that organism cells’ living depends on. Its physiological importance has been widely accepted. Interstitial fluid is responsible for the pathogenesis of some diseases and cell’s metabolism. This article is to investigate interstitial fluid flow in.ligaments and tendons such as inter osseous membrane on lower limb, where there is relatively fewer capillaries than in other tissues. Dissecting experiments have showed that the distribution of blood capillaries on inter osseous membrane is not organized into meshes, but parallel arrays on certain direction which is approximate to the direction of parallel collagen fibrils on interosseous membrane. This article concerns the influence of special distribution of capillaries and.collagen fibrils on interstitial fluid flow. This article discusses the flow of interstitial fluid in inter osseous membrane. Depending on the discovery of physiology dissection, the distribution of capillaries in inter osseous embrane is not organized into meshes, but regular parallel arrays. And collagen fibrils in inter osseous membrane is also organized into parallel arrays whose direction is approximately according to the direction of capillaries arrays. Based on these special distributions of capillaries and collagen fibrils, we build a two-dimensional saturated porous medium model to simulate interstitial fluid.flow and study the influence of capillaries and collagen fibrils on this flow. Through computing.the model, we receive interstitial fluid flow field on special parallel capillaries and discuss the.influence of capillaries, pressure and parallel collagen fibrils on the flow field. The result of computing demonstrates that these parallel capillaries and collagen fibrils play an important role on mechanics and physiology. Through analyzing the calculating results, the influence regularity of the vascular.hemodynamics parameter’s change on the interstitial edema’s (main symptom of Qi-Deficiency) formation was got, and quantitative relationship between the vascular hemodynamics parameters.and edema degree was given. Compared the theoretical results with the CQD research of clinical and animal experiments showed that our model could explain the physiological and pathological mechanism of CQD quantitatively. When the vascular parameters (for example, the total blood volume, the remote vascular resistance, and the cardiac contract force ) change, the interstitial volume will increase, and lead to the decrease of protein and other nutritious contents concentration. the Qi content of CQD is closely relative to the nutrition concentration in the tissue fluid, when more water moves from blood to the inter-tissue, the content concentration in tissue-fluid will decrease, which will affect cell’s physiological function and lead to symptoms of Qi-Deficient.

组织液是细胞间质的主要成分之一，它在细胞的生长与亡中起重要的作用。先前实验发现人体某些特定部位的组织液具有长距离定向流动特征，后来我们通过解剖观察到在这些特定部位毛细血管呈平行排列。本研究通过微观解剖观察和间质物性的测量，建立组织液流动的动力学模型并经活体实验验证来阐明组织液定向流动这一新的生理现象的机理和功能。