含氟手性试剂的合成及其在氟碳相不对称反应中的应用

Using perfluoroalkyl iodides, 2,2-Dihydropolyfluoroalkanoic acid and ethyl 2-hydropolyfluoroalkenoates as starting materials, various important fluorine-containing aromatic and hetrocyclic compounds such as perfluoroalkylated 1,1'-binaphthyl-2,2'-diols, 4-fluoroalkyl-2-quinolinols, 2-[1-hydropolyfluoro-1-alkenyl]-4H-3,1-benzoxazin-4-ones, 4-fluoroalkyl-2H- pyrido[1,2-a]pyrimidin-2-ones, 5-fluoroalkyl-12H-quinolino[2,1-b]quinazolin- 12-ones, 5-fluoroalkyl-isoxazolidines, 2-aryl-3-fluoroalkylcarbonylindoles and their derivertives were synthesis in this project for further investigation on their chemical and biological properties.

利用本实验室发展的全氟烷基化方法及其它合成技术，合成几种带有全氟烷基的1，1"-联萘-2,2"-二酚及其衍生物，并对它们在氟碳相体系中诱导的不对称反应进行研究，开发这些化合物在环境友好的氟碳相反应体系中作为手性诱导试剂的应用。..........