钛种植体抗感染医用涂层设计与关键技术研究

In order to solve the problem that the frequent occurrence of associated infection on titanium implant, the project makes an effort to establish a hybrid processing technique of microarc oxidation and hydrothermal treatment for surface modification of titanium through the fluorine salt in aqueous solution. With the key techniques，novel composite films composed of the SrF-doped hydroxyapatite nanofibers and titania oxide bi-layers are designed and prepared on the surface of titanium. The research interests of the project include: the formation mechanism mechanism of the composite films, structure characterization and bond mechanism of the interfaces between the adjacent phases, the effect of hydrothermal treatment parameters on the ratio of doping component and nanofiber diameter, structure and adhesion strength stability and its dependence on the structure of the layers, the effect of the ratio of doping component and nanofiber diameter on the response of cells and bacterial. By optimizing the structure of the bilayer coatings on the basis of the aforementioned investigations, it is expected to endow the coatings with high bond strength, bioactivity, antibacterial effect. It is the aim to make Ti implant with the function of preventing infection.

为了解决钛种植体术后相关感染频发的问题，本项目通过在水热介质中添加氟盐，改良优化微弧氧化和水热生长关键技术，在钛基表面设计并获得高结合强度的“SrF-HA纳米纤维/氧化钛”复合涂层；阐明复合涂层的形成机理及其各组相间的结合机制，揭示SrF-HA纳米纤维掺杂组元配比以及纤维直径与水热工艺参量的关系；考察复合层结构和结合强度长期稳定性与其结构组态的关系；阐明纳米纤维掺杂组元配比以及纤维直径对细胞和细菌的作用效应与机制，建立涂层高结合强度、生物活性和抗菌性的优化构建方案，以达到赋予钛种植体预防相关感染性能的目的。

为了解决钛种植体术后相关感染频发的问题，本项目通过在水热介质中添加氟盐，改良优化微弧氧化和水热生长关键技术，在钛基表面设计并获得高结合强度的“SrF-HA纳米纤维/氧化钛”复合涂层；阐明了复合涂层的形成机理及其各组相间的结合机制，揭示了SrF-HA纳米纤维掺杂组元配比以及纤维直径与水热工艺参量的关系；考察了复合层结构和结合强度长期稳定性与其结构组态的关系；阐明了纳米纤维掺杂组元配比以及纤维直径对细胞和细菌的作用效应与机制，建立了涂层高结合强度、生物活性和抗菌性的优化构建方案，以达到赋予钛种植体预防相关感染性能的目的。