频域OCT全眼组织结构及血流成像技术研究

Due to the refractive power of the anterior segment a light beam cannot be simultaneously focused on both the anterior segment and the post segment of human eye, and limited by the imaging depth, the traditional spectral-domain optical coherence tomography (SD-OCT) can not be used for real time whole eye segment imaging. Millions of people are affected by eye diseases like myopia, presbyopia, cataract, and glaucoma. These eye diseases can affect the shape of tissues and vessels of the whole eye. For examination of ocular accommodation and pathological changes caused by these diseases simultaneous high resolution imaging of the whole eye segments OCT system is desired. Based on our previous work on a dual focus dual channel SD-OCT for simultaneous imaging of the anterior segment and the retina, in this proposal, depth extended SD-OCT system for whole eye segment imaging (including the Ciliary muscle, Choroid and the vitreous) will be developed, in which the scanning range will be simultaneously extended. Techniques for high resolution and high sensitivity Doppler blood velocity detection and ocular angiography will also be studied. Furthermore, the eye accommodation and early eye uveitis will be studied with the whole eye segment SD-OCT for structural and functional imaging. Potential clinical application of our system may be in the detection of the pathological changes of the whole eye, and this SD-OCT system also provides a powerful imaging method for ophthalmic research, such as accommodation, ocular growth, and biometry of the eye.

眼调节及许多眼部病变会导致全眼范畴的组织结构及血流的变化，对全眼组织结构及血流的高分辨成像成为当前眼科研究及临床检测的切实需求。受眼科成像技术分辨率及检测深度的限制，此方面工作尚未得到有效开展。近年来，频域光学相干层析技术（SD-OCT）成像深度拓展研究、多普勒血流成像及高灵敏度微血管造影技术的发展使高分辨全眼组织结构及血流成像成为可能。申请人前期成功实现了同时对全眼前节及视网膜组织结构的高分辨成像，进行了精确测量视网膜绝对血流速度和微血管造影技术的研究。在此项目中，申请人及项目组成员将进一步研究包括深层组织的全眼成像深度拓展及血流成像技术，深入研究以全眼组织结构和血流为信息参数的眼调节特征，并尝试全眼性疾病检测。本项目突破传统光学相干层析技术的瓶颈，研究拓展成像深度及检测范围的全眼成像技术，探索包括深层组织结构及血流的全面人眼信息，其研究成果将为眼调节及眼病变研究提供理论与技术支持。

全球现在约有 1.8 亿人患有视觉残疾，其中4500 万人完全失明，每年又会新增2100 万低视力者。目前，我国约有500 万人失明，而屈光不正患者人数更是数以亿计。世界卫生组织(WHO)与世界诸多防盲非政府组织共同发起“视觉2020：享受看得见的权利”的全球行动。其中，人眼调节机制研究及病变检测工作是防盲治盲、视觉矫正及功能维护至关重要的内容。眼调节及许多眼部病变会导致全眼范畴的组织结构及血流的变化，对全眼组织结构及血流的高分辨成像成为当前眼科研究及临床检测的切实需求。受眼科成像技术分辨率及检测深度的限制，此方面工作尚未得到有效开展。近年来，频域光学相干层析技术（SD-OCT）成像深度拓展研究、多普勒血流成像及高灵敏度微血管造影技术的发展使高分辨全眼组织结构及血流成像成为可能。本项目完成了全眼OCT系统研制、全眼成像深度的拓展及眼调节机理、近视形成研究方面应用；多普勒血流成像及其应用研究；多模态成像系统研制及CNV、RNV眼病研究；基于深度学习、神经网络等算法的OCT图像分割、眼病分类的研究。项目研究成果将为眼调节及眼病变研究提供理论与技术支持。