动态亚胺键法合成高稳定性的分子笼多孔材料的研究

Cage compounds will be synthesized via dynamic imine bond formation using aldehydes bearing neighbouring hydroxyl groups and amines with certain spatial structures as building blocks. A novel synthetic method of highly stable molecular cages via tautomerization of the formed imine-enole to keto-enamine will be investigated. The influence of the sizes of substituents to the angles between amino groups, as well as its relationship with the Archimedean bodies of the formed cages, will be studied. The structure of the synthesized series of cage compounds will be characterized. The stability of the cage compound under acid-base conditions will be estimated via the change of surface area. The gas storing ability of these cage compounds to nitrogen, hydrogen, methane and carbon dioxide will be probed and the corresponding heating of gas adsorptions and gas selectivity will be calculated. The target of this project is to synthesize six to eight cage compounds, which will provide a new synthetic protocol for highly stable cage compound and give great significance in the exploration of application values of cage compounds.

以邻羟基醛类和具有一定立体结构的胺类为基本构建单元，利用动态亚胺键的形成来合成分子笼。研究亚胺键和相邻的酚之间异构化成酮-烯胺的反应条件，探索具有高稳定性的分子笼的合成新方法；研究取代基团的大小对氨基间夹角的影响及其与形成的分子笼的阿基米德体之间的关系，对所合成的系列分子笼化合物的结构进行表征；通过表面积变化的情况评估分子笼在酸碱条件下的稳定性；研究这些分子笼对氮气、氢气、甲烷和二氧化碳等气体的储存能力，并通过计算的手段研究分子笼的气体吸附热和气体选择性。通过本项目的研究，合成6-8个分子笼化合物，为具有高稳定性的分子笼的合成提供新的思路，对拓展分子笼的应用价值具有重要意义。