“喜胜忧”调节抑郁症患者负性认知偏向的神经机制研究

Depression is a kind of Serious Disorder，which brings heavy burden to patients and society. Delighting adjusting sorrow therapy, based on Traditional Chinese Medicine (TCM) emotions interaction theory, has been used in treatment for depression. Our research group has treated depression by the therapy, achieving confirmable curative effect. The mechanism of Delighting adjusting sorrow therapy was studied in the field about Qi activity, Yin-Yang and five elements. We propose that delighting would adjust the cognitive control insufficient or processing enhance of negative emotions. In this study, as a 2×2×2 between-subjects design, the research subjects, including depressed patients and healthy ones, will be divided into four groups: delighting depressed subjects, non-delighting depressed subjects, delighting healthy subjects and non-delighting healthy subjects. The experimental data, containing behavioral results, ERP components and sLORETA traceable information, will be collected by event-related potential technique. We will explore the neural mechanisms of delighting process how adjust the negative cognitive processing bias in depressed patients. The result could provide the experimental basis for TCM emotions interaction theory and delighting adjusting sorrow therapy.

抑郁症是严重的情感障碍性疾病，给患者和社会带来沉重负担。“喜胜忧”疗法基于中医情志相胜理论，在抑郁干预中多有应用，本团队用其干预抑郁，疗效确切，有一定研究基础。对其作用原理，目前学界仅有气机、五行等理论探讨，尚未见神经机制研究。本研究假设“喜胜忧”疗法干预抑郁时，“喜”的激活能调整负性情绪认知控制不足或加工增强阶段，拟选取抑郁症患者和健康被试各30例，分别随机纳入“喜”激活、未激活抑郁组与“喜”激活、未激活健康组，根据组别，应用“喜”情志激活的标准化规程或对照方案干预，采用2×2×2的被试间设计，进行靶刺激改良的情绪启动效应实验，以相关事件电位（ERP）技术采集数据，分析四组被试的行为学、ERP成分、sLORETA溯源结果，探索“喜”调整抑郁症患者的负性认知加工偏向的神经机制，阐明其起效的“心理靶点”，为中医情志相胜理论治疗抑郁症提供实验基础，并制订规范化“喜胜忧”干预抑郁方案供临床应用。

抑郁症（Depression）是严重的情感障碍性疾病，给患者和社会带来沉重负担。“喜胜忧”基于中医情志相胜理论，在抑郁干预中多有应用，效果确切。本团队以情志相胜疗法干预抑郁，已有临床与试验基础。对其作用机制，目前学界仅有气机变化、阴阳五行等理论探讨。本研究假设“喜胜忧”疗法干预抑郁时，“喜”的激活能调整负性情绪认知控制不足或负性情绪加工增强阶段。本课题招募了轻中抑郁症患者和正常被试共110例作为研究对象，应用情志激活的标准化规程，以相关事件电位（ERP）技术采集脑电数据，比较不同被试在行为学、ERP成分、sLORETA溯源等数据的差异，探索“喜”激活调整抑郁症患者的负性认知加工偏向的认知神经机制，为中医情志相胜理论治疗抑郁症提供实验基础。本课题运用中医情志理论，参照现代心理学测量原理与方法，制订了标准化的“喜”“忧”情志激活视频材料库，包括诱发快乐情绪的视频21个，诱发悲伤情绪的视频8个，诱发平静情绪的中性视频13个，每个视频片段均包含了靶情绪类型、时长、击中率、情绪强度、效价、唤醒度、动机强度指标，可为中医情志相胜疗法的现代研究提供标准化工具。脑电数据结果主要在顶区、额区引发了P170、N2两种内源性脑电成分，两种成分的最大峰值均出现在额区。脑电数据结果显示，P170潜伏期在被试组别、情志激活类型和脑区位置三者之间存在交互作用。