多功能石墨烯/聚合物纳米复合载药微粒及其在乳腺癌诊疗中的应用基础研究

Novel multifunctional drug carriers were prepared by using nano graphite oxide, graphene quantum dots, thermosensitive polymers as building blocks. In this drug delivery system, the nano graphene oxide and graphene quantum dots were introduced to the inner and surface of polymer microgels respectively via hydrogen bonds. The drugs were loaded on the surface of graphene and inside of polymer microgel through π-π or hydrogen interactions. During treatment of cancer, the photothermal effect with near-infrared light of graphene could not only play a thermotherapy effect, but also helps to inducing controlled drugs releasing. Function of tracing of the drug carriers were realized via graphene quantum dots attached thereto. One of the advantages of this drug carrier is its simple preparation method. The other is that the Synergistic effect of between the building blocks is conducive to realize the diagnosis and treatment of breast cancer simultaneously.

本项目以纳米氧化石墨烯、石墨烯量子点、温敏聚合物等为基本单元构建一种新型的多功能纳米药物载体。该载药体系中，氧化石墨烯和石墨烯量子点通过与温敏聚合物之间的氢键相互作用分别被引入到温敏性聚合物微凝胶内部和外表面，药物分别通过π-π和氢键作用负载于石墨烯表面和微凝胶内部。在癌症治疗中，体系中石墨烯特有的近红外光热效应不仅可以起到热疗效果，其升温效应有助于诱导药物可控释放。石墨烯量子点可以实现肿瘤的靶向成像示踪功能。该载药体系的优势在于制备方法非常简单，且各基元间的协同作用有利于实现乳腺癌的诊疗一体化。

本项目以纳米氧化石墨烯、纳米硫化铜、以及/或石墨烯量子点与温敏聚合物为基本单元制备了新型的多功能纳米药物载体。该载药体系中，CuS、氧化石墨烯和石墨烯量子点通过与温敏聚合物之间的氢键以及静电相互作用分别被引入到温敏性聚合物微凝胶内部或外表面，药物分别通过π-π和氢键作用负载于石墨烯表面和微凝胶内部。其中氧化石墨烯和CuS具有近红外光热效应，可以起到热疗效果，并且其升温效应有助于诱导药物可控释放。