胃肠道间质瘤(GIST)是一类组织了生不明确.恶性程度预后评估缺乏特有指标间叶肿瘤。本项目采用PCR-SSCP.DNA测序COS回归分析等方法,确定GIST恶性变化相关C-kit基因突变嘈停治鯟-kit突变与GIST恶性及预后的关系,并将突变片段体外转染细胞株,体内接种裸鼠,观察基致癌性并探索突变致可能途径,为GIST致致癌机理研究.诊断及预后评估提供依据。.
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数据更新时间:2023-05-31
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