甲状腺肿瘤中红外光谱频率上转换探测

Thyroid tumor is a common disease in people's neck and thyroid cancer has the highest incidence among all the malignant tumors in endocrine organs, representing about 1% of the human malignant tumors. Recently, the incidence of this disease is rising year by year, significantly threatening people's health. Compared to other cancers, the thyroid cancer has a higher cure rate if it is timely discovered, so its early diagnosis is very important. At present, the inspection of the thyroid tumor is based on traditional surgical specimens, nuclear magnetic resonance scanning, thyroid isotope scanning and the emerging biopsy cytology. However, accurate diagnosis of the thyroid tumor cannot be achieved by all the methods mentioned above. In recent years, the mid-infrared spectroscopy has a good application perspective in thyroid tumor research for its advantages of fast speed, noninvasive and high accuracy. But, mid-infrared photons cannot be sensitively detected because of its weak energy and other external thermal interference. While, mid-infrared frequency up-conversion is not constrained by the detection materials (utilizing one to one conversion), paving a new way for mid-infrared sensitive detection. This project proposes to convert the mid-infrared thyroid spectrum to the visible or infrared region and then detect with a silicon detector, so as to provide a reasonable basis for diagnosing the thyroid tumor.

甲状腺癌相对于其它癌症，如果发现及时预后情况一般较好，因此甲状腺癌的早期诊断显得尤为重要。传统的检测手段均不能使甲状腺肿瘤得到准确的判断，近年来新兴的利用中红外光谱研究甲状腺肿瘤具有快速、无创和准确率高等优点，具有良好的应用前景。该技术的发展需要中红外波段灵敏探测的有力支持，然而该波段探测器的性能受限于光子能量过于微弱及外界热辐射的干扰。红外频率上转换探测技术可不受探测器对波长的响应限制，将中红外信号完全转换到可见光或近红外波段，为中红外灵敏探测提供了新方式。本项目提出利用高峰值功率的锁模光纤激光器作为泵浦源，解决医学检测中，光路发散角大，光谱宽等特点对频率上转换探测的影响。利用脉冲泵浦方式将背景噪声局限在探测时间窗口内，研究环境热辐射对系统的影响。最终实现将甲状腺中红外光谱信号转换到近红外波段，利用近红外波段探测器实现灵敏探测，进而为准确判断甲状腺肿瘤提供合理依。