癌症免疫机理的数学建模与计算机模拟

The cancer (malignant solid tumor) mortality is higher than that of all other diseases by the "Dataset of the National Health and Family Planning of the People's Republic of China" in Volume 2017, and keeps increasing. Cancer is a genetic disease, which is led by a series of mutations in the genome of the tissue stem cells. It is generally thought to develop slowly over 15-20 years from the early mutation to clinical detection. The tissue invasion and metastasis of malignant cells cause the death of the patients. In developed country, the.incidence of breast cancer is higher than that of all other cancers. In our country, the incidence of breast cancer keeps increasing. Immune therapy is the hottest topic for cancer research in the present, which is also the most effective treatment of cancer patients at the stage of tissue invasion and metastasis. In this project, our aim is to research the interaction mechinism between the immune.system (the innate immune system and the adaptive immune system) and all intermediate cells, to provide the theoretical basis for the control, prediction and therapy of the breast cancer by mathematical modeling and computer simulation of the epidemilogical dataset of breast cancer. We will research the control, prediction, early diagnose and therapy of cancer at the molecular leval by using.the idea of control and prediction the epidemic spread and the epidemic dynamical model.

根据《中国卫生和计划生育统计年鉴》2017卷统计数据，癌症（恶性肿瘤）病人的死亡率位居所有主要疾病死亡率之首位并且呈现逐年上升的趋势。癌症（恶性肿瘤）是组织干细胞一系列累积变异（或突变）的结果，从正常组织干细胞开始变异到临床发现一般大约需要15-20年时间，癌症病人死亡的主要原因是癌细胞的扩散（或转移）。在发达国家，乳腺癌发病率位居女性恶性肿瘤第一位，在我国女性发病率逐年上升。癌症的免疫疗法是当前癌症研究领域里最热门的课题，也是治疗晚期癌症病人最有效的方法。本课题将利用乳腺癌流行病学数据，探讨乳腺癌的形成过程中变异细胞与人体免疫系统（包括先天免疫系统和适应性免疫系统）之间的相互作用机理，为乳腺癌的预防控制和治疗提供理论依据。我们将在分子水平上利用传染病传播（或病毒免疫作用）模型研究癌症的预防控制、早期诊断与治疗。

根据《中国卫生和计划生育统计年鉴》2017卷统计数据，癌症（恶性肿瘤）病人的死亡率.位居所有主要疾病死亡率之首位并且呈现逐年上升的趋势。癌症（恶性肿瘤）是组织干细胞一.系列累积变异（或突变）的结果，从正常组织干细胞开始变异到临床发现一般大约需要15-20.年时间，癌症病人死亡的主要原因是癌细胞的扩散（或转移）。在发达国家，乳腺癌发病率位.居女性恶性肿瘤第一位，在我国女性发病率逐年上升。癌症的免疫疗法是当前癌症研究领域里.最热门的课题，也是治疗晚期癌症病人最有效的方法。本课题将利用乳腺癌流行病学数据，探.讨乳腺癌的形成过程中变异细胞与人体免疫系统（包括先天免疫系统和适应性免疫系统）之间.的相互作用机理，为乳腺癌的预防控制和治疗提供理论依据。我们将在分子水平上利用传染病.传播（或病毒免疫作用）模型研究癌症的预防控制、早期诊断与治疗。