生物相容茂金属嵌段高分子：一种新型智能材料的设计与应用

In recent years, metal-containing polymers have received a lot of attention due to their combination of the advantages from polymer frameworks and inorganic metals. This research will majorly investigate on a novel kind of metal-containing polymers based on polycaprolactone (PCL) and cobaltocenium, especially on their controlled radical polymerization techniques and solution self-assembly behaviors. Considering the extremely low toxicity and strong ability to kill bacteria from cobaltocenium-containing polymers, PCL based cobaltocenium-containing block copolymers and their self-assemblies will be studied as possible antimicrobial materials and biodegradable soft matters for drug delivery. Besides, due to unique ion-dependent solubility and redox properties for cobaltocenium moieties, the ionic and redox responsive ability of these novel block copolymers will be also discussed and further applied to design 'smart‘ and functional materials.

近年来，金属杂化高分子材料引起了广泛的关注。金属高分子既含有高分子材料的力学性能和可加工性能，还具有金属有机小分子的功能特点，如催化，生物和电化学性能等等。本课题将重点研究含茂金属的聚己内酯（PCL）嵌段共聚物的合成和应用，主要研究二茂钴（Cobaltocenium，Cc）和PCL的嵌段共聚物(PCL-b-PCc)的自由基可控聚合方法，并研究这类软物质的溶液中的三维结构和其自组装机理。考虑到二茂钴高分子很低的生物毒性和良好的抗菌性，其自主装体的生物活性（抗菌性）、生物降解性能和药物传输功能也会被进一步研究。此外，由于独特的二茂钴金属离子响应亲疏水性质和金属电化学特性，嵌段共聚物(PCL-b-PCc)的电化学响应和离子响应将被深入探讨。基于这些特点，嵌段共聚物(PCL-b-PCc)也被用于制备多重智能响应软物质材料和设计高效率的药物传输系统。

近年来，金属杂化高分子材料引起了广泛的关注。本课题实现了含茂金属的聚己内酯（PCL）嵌段共聚物的合成和应用，主要研究了二茂钴(Cobaltocenium，Cc) 和PCL的嵌段共聚物(PCL-b-PCc)的自由基可控聚合方法，并探索了这类软物质的溶液中的三维结构。此外，由于独特的二茂钴金属离子响应亲疏水性质和金属电化学特性，嵌段共聚物(PCL-b-PCc)的电化学响应和离子响应也被深入探讨，并成功实现了聚合物的此方面响应。除此之外，课题还进一步探讨了其他含金属杂化高分子的合成与功能，实现了杂化金属高分子的发光特点，响应特点以及其功能化的应用。