金属有机框架杂化光响应印迹识别材料的制备与传感应用

The high specificity to the target of the molecularly imprinted polymers (MIPs) makes them an important research hotspot to design the sensing elements of high-selectivity and high-sensitivity sensor. However, conventional MIPs have problems such as low bonding capacity and slow bonding/dissociation kinetics. So, this project intends to obtain hybrid imprinting identification materials by surface imprinting polymerization on to the surface of metal organic framework with high specific surface area and porosity，besides designing and using functional monomers containing azobenzene photoresponsive groups. Though these two approaches, the binding sites are located on the surface or near the surface of the polymer and their spatial configuration could be easily changed via the light-inducing isomerization of these functional monomers. Consequently, the bonding capacity and the bonding/dissociation kinetics of the hybrid MIPs could be effectively increased. In addition, the project also intends to connect the hybrid MIPs to the transducer by click chemistry, which might improve the performance of the constructed sensors in terms of detection limit, sensitivity and stability. The research of this project will greatly improve the performances of the sensors based on MIPs, and provide important experimental and theoretical basis for their extensive applications in the analysis and detection fields of health, environment and food safety. Besides that, it also has important scientific significance and broad application prospects.

分子印迹聚合物因其对目标物具有高特异性而成为了高选择性、高灵敏度传感器感应元件设计领域的一个重要研究热点。然而，传统印迹聚合物存在成键容量低、成键/解离动力学慢等问题。鉴于此，本项目拟通过在高比表面积、多孔隙率的金属有机框架结构表面进行表面印迹聚合和设计使用含偶氮苯光响应基团功能单体的策略，来制得杂化印迹识别材料，使成键位点基本位于聚合物的表面或近表面处，并借助光诱导功能单体异构化引起成键位点空间构型的变化，来有效地增加杂化分子印迹聚合物的成键容量，提高其成键/解离动力学。另外，本项目还拟通过点击化学反应，将杂化分子印迹聚合物连接至换能器，以提高所构筑传感器在检出限、灵敏度和稳定性等方面的性能。本项目研究将较大程度地提高基于分子印迹聚合物传感器的传感性能，为其广泛应用于健康、环境、食品安全等领域的分析检测提供重要的实验和理论依据，具有重要的科学意义和广阔的应用前景。

在项目21904025的资助下，我们结合金属有机骨架化合物比表面积大和易于化学改性、层状双金属氢氧化物的阴离子交换性能、棉纤维超强的形状可调性和易于修饰等优点，构筑了几种对非甾体抗炎药具有高分离富集性能的吸附材料，实现了对非甾体抗炎药进行有效地分离富集。主要表征了复合材料的结构，优化了分离富集条件，研究了复合材料的吸附容量及成键/解离动力学，并初步进行了实际水样应用研究。本项目研究可为表面功能吸附材料的制备、表征、应用提供理论支持与技术保障，研究成果对于健康、环境和食品安全等领域污染物的分析检测和去除具有十分重要的意义。项目执行期间，共发表SCI论文2篇，指导培养硕士研究生2名。