补体攻膜复合物(MAC)刺激肾小管上皮细胞表达B7-H1的分子机理研究
基本信息
结项摘要
前期的研究我们发现补体攻膜复合物（MAC）可刺激人肾小管上皮细胞（TEC）表达共刺激分子B7-H1并调节T细胞功能，首次证明了天然免疫可通过共刺激分子调T细胞免疫。然而MAC刺激B7-H1表达的分子机理尚未清楚。已有的研究表明NF-κB在MAC所激发的各种效应中处于核心地位，并发现NF-κB p50-/-树突细胞B7-H1表达也受影响。因此推测NF-κB可能参与MAC诱导的B7-H1表达。本文拟体
项目摘要
项目成果
{{i.achievement_title}}
{{i.achievement_title}}
暂无此项成果
数据更新时间：2023-05-31
其他相关文献
DNAgenie: accurate prediction of DNA-type-specific binding residues in protein sequences
DNAgenie: accurate prediction of DNA-type-specific binding residues in protein sequences
黄曲霉毒素B1检测与脱毒方法最新研究进展
黄曲霉毒素B1检测与脱毒方法最新研究进展
Quasispecies characteristic in "a" determinant region is a potential predictor for the risk of immunoprophylaxis failure of mother-to-child-transmission of sub-genotype C2 hepatitis B virus: a prospective nested case-control study.
Quasispecies characteristic in "a" determinant region is a potential predictor for the risk of immunoprophylaxis failure of mother-to-child-transmission of sub-genotype C2 hepatitis B virus: a prospective nested case-control study.
Interferon-based treatment is superior to nucleos(t)ide analog in reducing HBV-related hepatocellular carcinoma for chronic hepatitis B patients at high risk
Interferon-based treatment is superior to nucleos(t)ide analog in reducing HBV-related hepatocellular carcinoma for chronic hepatitis B patients at high risk
Interfering with long non-coding RNA MIR22HG processing inhibits glioblastoma progression through suppression of Wnt/β-catenin signalling
Interfering with long non-coding RNA MIR22HG processing inhibits glioblastoma progression through suppression of Wnt/β-catenin signalling
贾正才的其他基金
相似国自然基金
补体攻膜复合物细胞非致死效应发生机制的研究
络衡方调节补体攻膜复合物C5b-9生物活性表达的物质基础研究
负性协同刺激分子B7-H1在胃癌组织中表达的调节机制研究
补体膜攻击复合物C5b-9介导三氯乙烯免疫性肾小管损伤机制研究