调控羟基磷灰石纳米晶定向生长及取向有序排列的研究

Templates (amino acids and collagen-like organic matrix) combined with extra condition were used to investigate directional growth and oriented arrangement to mimic the process of bone formation. The regulation of hydroxyapatite nanocrystals directional growth involves self-assembly while the oriented grow and ordered arrangement. To reveal nano-hydroxyapatites deposited orientation in the process of the growth pattern for preparing bone repair materials, the interactions between the crystal growth behavior, molecular configuration, molecular groups and extra accelerating and facilitating methods were studied. This project provides clues for structure biomimetic bone repair material further on the basis of the biomimetic ingredients.

采用类胶原作用的有机模板，结合施加促进反应条件，利用取向附着调控羟基磷灰石纳米晶在定向生长的同时实现众多晶体的取向有序排列，探讨骨形成过程中磷灰石纳米晶的定向生长和取向排列机制；通过分析晶体生长行为与分子构型构象、分子基团之间的相互作用关系，结合考察施加手段的加速和促进作用，揭示体外模拟骨形成过程众多纳米羟基磷灰石择优取向沉积的生长规律，为在成份仿生基础上，体外构建结构仿生型骨修复材料提供理论基础和研究数据。

针对体外还无法构建出具有类骨结构、力学性能优越的骨修复材料，本研究从氨基酸入手，采用有机模板结合施加促进反应条件，调控羟基磷灰石纳米晶在定向生长的同时实现众多晶体的取向有序排列，探讨骨形成过程中磷灰石纳米晶的定向生长和取向排列机制。研究合成条件和纳米羟基磷灰石晶体本身形貌和其取向排列生长行为，研究外在施加合成条件、有机模板的构型构象、基团与羟基磷灰石纳米晶取向有序排列之间的构效关系。在国内外学术刊物上发表论文17 篇，其中SCI收录16 篇，EI收录1篇；申请国家发明专利5项（已授权4项）;已培养研究生3 名。获福建省高等学校新世纪优秀人才支持计划、福州青年科技奖等奖励或荣誉。