生物力学因素在早期骨关节炎形成中诱导机制的影像学研究

Joint pain is the most common clinical problem in adult population, and the first leading cause of disability worldwide. As a international medical and social problem, joint pain is closely associated with OA. Therapeutic intervention has been invalid because the abnormal biomechanical response that inducs OA has not been hampered. Studies suggest that abnormal mechanical load acts as a trigger in OA, and the cellular and molecular biomechanical response results in OA. So non-invasive in vivo imaging of cellular and molecular biomechanical response in early OA, which will provide a reliable basis for early treatments, is a scientific problem to be solved..This project is about the imaging of the biomechanical for inducing early OA under abnormal mechanical load. The contents are as follows: 1. imaging of articular cartilage cnutrient source (porosity and capillary); 2. imaging of articular cartilage cellular autophagy; 3. imaging of biochemical composition for articular cartilage matrix . The goal of this study is to achieve non-invasive in vivo imaging of the biomechanical mechanism for inducing early osteoarthritis under abnormal mechanical load. We are trying to offer an effective technical approaches for early diagnosis and early prediction of OA, and creating a new field of imaging studies.

OA是成年人发病率最高的疾病，临床缺乏有效治疗，原因是未从源头上阻断或延缓其发生发展。研究证明生物力学因素在诱导OA形成中至关重要，但目前相关的基础研究缺乏向临床应用转化的手段，无法服务于早诊早治。因此，将细胞及分子生物力学与影像技术有机结合，实现生物力学因素诱导早期OA形成的无创性活体成像，是临床有效治疗OA的前提，是亟待解决的科学问题。.该申请项目致力于通过生物力学因素诱导早期OA形成机制的影像学成像，包括：1.关节软骨营养源（孔隙率和微血管）成像；2.关节软骨细胞自噬成像；3.关节软骨细胞外基质的生化成像，明确异常应力诱导早期OA形成的分子成像和病理成像特征，从理论上建立一套生物力学因素诱导早期OA形成的发病机制的影像诊断方法，开创活体无创性成像生物力学因素诱导早期OA形成机制的研究领域。

OA是成年人发病率最高的疾病，临床缺乏有效治疗，原因是未从源头上阻断或延缓其发生发展。研究证明生物力学因素在诱导OA形成中至关重要，但目前相关的基础研究缺乏向临床应用转化的手段，无法服务于早诊早治。因此，将细胞及分子生物力学与影像技术有机结合，实现生物力学因素诱导早期OA形成的无创性活体成像，是临床有效治疗OA的前提，是亟待解决的科学问题。 .该申请项目致力于通过生物力学因素诱导早期OA形成机制的影像学成像，包括：1.关节软骨营养源（孔隙率和微血管）成像；2.关节软骨细胞自噬成像；3.关节软骨细胞外基质的生化成像，明确异常应力诱导早期OA形成的分子成像和病理成像特征，从理论上建立一套生物力学因素诱导早期OA形成的发病机制的影像诊断方法，开创活体无创性成像生物力学因素诱导早期OA形成机制的研究领域。