大肠癌发生机制的adenoma-adenocarcinoma pathway同serrated pathway的关系的研究
基本信息
结项摘要
随着对大肠锯齿状腺瘤(Serrated adenoma, SA)研究的进展，在大肠癌发生机制中一个serrated neoplasia pathway被提出。但其实质还是不明的。SA的腺管是由突入管腔内部分的高柱状细胞和凹面部分的短柱状细胞组成的。我们最近的研究已证明SA的凹面部分的短柱状细胞表达Wnt/β-catenin pathway 蛋白质；而突入管腔内部分的高柱状细胞和表达终末分化标志物。本研究拟分别分析SA的高柱状细胞和短柱状细胞的Wnt/β-catenin pathway 蛋白，APC蛋白和错配修复基因MLH1和MGMT蛋白表达；APC，β-catenin，K-ras和BRAF基因的突变及MSI和DNA甲基化的状况。从而阐明大肠癌发生的serrated neoplasia pathway的实质及其与adenoma-adenocarcinoma pathway的关系。
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数据更新时间：2023-05-31
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