Spred-2的造血调控作用及机制研究
基本信息
结项摘要
造血生长因子通过不同的信号转导途径调节造血干细胞的增殖和分化。Spred-2是新近发现的细胞增殖信号抑制分子。但是，其在造血调控中的作用并不清楚。本研究将利用慢病毒介导的基因转移方法，将Spred-2基因、RNA干扰序列导入人造血干细胞，以RFP为标记，通过细胞分选、细胞信号途径检测、造血细胞体外性能分析、造血重建及体内增殖分化特性分析等手段，确定高表达和基因沉默Spred-2 对造血干细胞增殖分化特性的影响，阐明Spred-2在造血调控中的作用。预期将为造血干细胞体外扩增及应用提供新的策略。
项目摘要
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数据更新时间：2023-05-31
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