超声造影剂微气泡次谐波及超谐波效应定量检测肺动脉压力的研究

Pulmonary hypertension(PH) is a common disease in clinical, which is measured by right heart catheterization invasively for seriously ill patients. Most patients with PH rely on the measurement of Doppler ultrasound, however, the accuracy and repeatability is poor.Therefore, developing more safe and accurate method is in high demand for improving PH diagnosis. This project aims to develop methods to measure pulmonary artery pressure based on sub- and ultra-harmonic responses from ultrasound contrast agent microububbles. In the preliminary study, we will modify the theoretical model of sub- and harmonic responses by considering the blood flow; find the relationship between the ambient pressure and the sub- or ultra-harmonic response; discuss the influence of ultrasonic and microbubble parameters on the measurement. Further in the animal experiment, we will develop an animal model for PH, and measure the pulmonary arterery pressure by using sub- and ultra-harmonic responses, and compare with the resutls by catheter. This project will further promote a new technology of the ultraharmonic-aided pressure estimation from ultrasound contrast microbubbles in the clinical application.

肺动脉高压为临床上常见病，临床采用右心导管有创准确测量，主要应用于重症患者。而普通的肺动脉高压患者多依赖多普勒超声测量，但准确性及可重复性均较差。故探寻一种无创且更加准确测量肺动脉高压的方法具有巨大的临床应用前景。本项目旨在研究超声造影剂微气泡的次谐波和超谐波效应测量肺动脉压力。在基础研究方面，拟考虑血流环境对次谐波超谐波效应的影响以完善超声造影剂微气泡振动理论，阐明研究超声造影剂微气泡次谐波及超谐波效应与外周压力的关系，探讨微气泡参数，超声作用参数对测量的影响，优化次谐波及超谐波效应血压测量技术；而在动物试验研究中，将建立肺动脉高压动物模型，将超声造影微泡次谐波和超谐波效应测得的肺动脉压力与有创压力导管测得的压力进行比较。本研究将进一步促进基于超声造影剂微气泡超谐波效应的压力辅助测量新技术在临床上应用。

肺动脉高压为临床上常见病，目前采用右心导管有创准确测量，主要应用于重症患者。而普通的肺动脉高压患者多依赖多普勒超声测量，但准确性及可重复性均较差。故探寻一种无创且更加准确测量肺动脉高压的方法具有巨大的临床应用前景。本项目通过超声造影剂微气泡的次谐波效应无创测量肺动脉压力。在基础研究方面，我们探讨了血流环境对次谐波效应的影响，完善了超声造影剂微气泡振动理论，阐明超声造影剂微气泡次谐波效应与外周压力的关系，并探讨微气泡参数，超声作用参数对测量的影响，优化次谐波效应血压测量技术；在动物试验研究中，我们建立了肺动脉高压动物模型，将超声造影微泡次谐波效应测得的肺动脉压力与有创压力导管测得的压力进行比较。本研究将进一步促进基于超声造影剂微气泡次谐波效应的压力辅助测量新技术在临床上应用。