直接测序法筛查中国人2型糖尿病家系及群体GCK、HNF-1α基因突变及突变家系临床病理生理研究
基本信息
结项摘要
糖尿病目前已成为人类的第三大杀手，尤其是中老年人致残致死、生活质量下降的最主要疾病之一，其中绝大多数是由多基因作用和环境因素影响所致的常见型2型糖尿病。而多基因糖尿病的病因学及发病机理复杂，基因型与临床表型的联系更难，所以至今未取得突破性的进展。近年国外的某些单基因突变糖尿病（如GCK基因）研究发现其有一定的临床特点。本项目以目前两个常见的单基因突变-GCK和HNF为切入点，在不同临床特点的糖尿病
项目摘要
项目成果
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数据更新时间：2023-05-31
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