全自动并行式同位素固相萃取仪研制

The multi-collector inductively coupled plasma mass spectrometry not only expanded the application field of solid isotope, but also dramatically improved the analysis throughput for high-precision isotope measurements. However, the progress of isotope sample pretreatment technology was very slow, compared with the development of isotope mass spectrometer technology, which has gradually become the bottleneck of isotope sample analysis. The main reseason is manual drip chromatography required for sample purification. In order to solve this problem, many researchers have already done a lot of useful work. Recently, there have also been instruments desigined for the separation and enrichment of isotope samples, which have promoted the technology of isotope separation and enrichment to a degree, but have not fundamentally eased this difficulty.. Therefore, we intend to develop a high-throughput and automated instrument for isotope separation and enrichment, based on the previous achievements, in order to improve the isotope separation and enrichment technology, and to free researchers from tedious manual labor.

多接收电感耦合等离子体质谱仪的出现和不断完善，不仅拓展了固体同位素应用领域，也极大地提高了同位素测试速度。然而，与同位素质谱仪技术进步的速度相比，同位素样品前处理技术的进步非常缓慢，已逐渐成为同位素样品分析的瓶颈，而制约同位素样品前处理的关键在繁琐、耗时的同位素分离富集环节。为解决这一难题，国内外学者已经开展了许多有益的工作，最近也出现了针对同位素样品分离富集的仪器，在一定程度上促进了同位素分离富集技术的发展，但并未从根本上缓解这种困境。. 鉴于此，本项目在借鉴前人的研究成果基础上，以研制高通量全自动同位素分离富集仪器为内容，期望有助于同位素分离富集技术发展，以释放同位素研究人员的活力。

针对同位素地球化学样品分离富集过程繁琐耗时难题，完成了全自动并行式同位素固相萃取仪研制。主要包括试剂注射、试剂选择、三维定位、固相萃取柱阵列、洗脱液收集、淋洗曲线收集、控制7个单元。试剂注射单元最大体积30 mL、注射精度为 0.1 mL，可在线配制混合溶液，耐受强化学腐蚀，超低金属元素本底；试剂选择单元耐受强化学腐蚀；三维定位单元准确可靠、耐受强化学腐蚀；固相萃取柱阵列单元避免空气栓塞，能自动判断交换柱液位；收集单元自动收集100分组分；淋洗曲线收集单元能以0.5mL间隔准确收集80个组分。仪器胜任放射性成因同位素和非传统同位素固相萃取，分离富集效果与经典人工分离效果完全一致，分离效率提高近5倍左右。系统可用于同位素地球化学和放射性化学元素分离富集，大大提高了固体同位素样品分析通量，减少了有害、有毒、放射性物质对操作人员的危害。