以vp22和泛素为基础的乙肝治疗性核酸疫苗的研究
基本信息
结项摘要
基于目前对慢性乙型肝炎（CHB）尚无有效治疗手段。本研究旨在根据HBV感染后，机体产生免疫应答的特点，利用RNA干扰技术特异性降解HBV的关键基因HBx mRNA，以抑制HBV其他蛋白的表达，从而降低病毒负荷，以HBVc作为免疫抗原基因并与单纯疱疹病毒－1的结构蛋白vp22及泛素（UBQ）构建成融合基因表达元件，利用vp22和UBQ的特性特异性增强核酸苗的免疫应答，进一步提高病毒清除率。并引入四环
项目摘要
项目成果
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数据更新时间：2023-05-31
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