3D凝胶剂量计辐射发光材料研制及性能分析

Radiotherapy is one of the main methods for treating cancer, and its key technique is accurate dose verification. In this study, with hydro-gel containing organic scintillatorvas research object, Light response is introduced to prepare a new type of real-time 3D-hydrogel dosimeter for preparation and basic research of the performance of hydro-gel material experimentally and theoretically. First, hydro-gel material containing organic scintillator was prepared and its performance was tested. Second, with CCD to collect Fluorescence response signal from different directions, we calculated the 3D dose distribution of hydro-gel material under high energy X-ray irradiation to test the dose verification performance. Meanwhile, Monte Carlo dose verification is also used to simulate calculation of 3D dose distribution of the hydro-gel material under irradiation to verify the dose verification effect. Based on the above test results, we finally realized good performance of hydro-gel in dose verification by continuous-optimization of experiment materials and conditions. The aim of this study is to prepare a new-type of hydro-gel dosimeter, which would furnish clinical dose verification with new technique and methods.

放射治疗是癌症治疗的主要方式之一。精准的剂量验证技术是放疗领域的一项重大课题。本课题将有机闪烁体与射线的光响应引入到剂量验证技术中，制备一种新型的即时3D凝胶剂量计，并以载有有机闪烁体的水凝胶为研究对象，采用实验室实验和理论计算相结合的方法，对凝胶材料的制备和性能进行基础科学研究。具体内容包括：采用辐射法一步制备载有有机闪烁体的水凝胶材料，并检测材料的基本性能，优化反应条件；利用医用直线加速器产生的高能X射线和离子束辐照凝胶材料，通过CCD收集不同角度的荧光响应信号，软件拟合重建辐射过程中的三维剂量分布，检测材料的剂量验证性能；同时通过蒙特卡罗方法模拟计算凝胶材料在辐射过程中的三维剂量分布，反馈和验证材料的剂量验证结果，对材料的制备和剂量验证提供一定的理论指导。本项目旨在以光信号作为响应信号，制备一类新型的凝胶剂量计，为临床剂量验证技术提供一种新技术手段和研究思路。

放射治疗是癌症治疗的主要方式之一。精准的剂量验证技术是放疗领域的一项重大课题。本研究将射线的光响应引入到剂量验证技术中，制备一种新型的即时 3D 凝胶剂量材料，并以载有发光体的水凝胶为研究对象，采用实验室实验和理论计算相结合的方法，对凝胶材料的制备和性能进行基础科学研究。实验结果表明：采用辐射一步法制可以制备负载有闪烁体（量子点或有机闪烁体）的水凝胶材料，检测结果表明，量子点水凝胶发光材料中，量子点良好的分散到水凝胶中，水凝胶具有良好的透光度，有利于光的读出和刻度。而载有有机闪烁体的水凝胶材料，显示出辐射发光响应，并且对剂量有一定的响应。本研究成功的将量子点、稀土纳米颗粒、有机闪烁体引入到水凝胶体系，制备了具有辐射发光性能的水凝胶，并且对其性能进行了检测。制备一类新型的凝胶剂量材料，为临床剂量验证技术提供一种新技术手段和研究思路。