笼状无机/有机杂化阴离子的导向功能化及其应用

The project presented in this proposal focuses on the advancement of the chemistry of a family of cluster compounds with high potential for future applications. Boron-based cage anions with the CB11- and B122- core are inorganic/organic hybrid molecules which possess unique steric and electronic properties that differentiate them from common metal complexes and organic molecules. Furthermore, they are very stable and exhibit low toxicity. Publications from the recent literature have demonstrated their utility in stereoselective synthesis, fluorescence/phosphoresence applications, materials science and biological chemistry and thus are also of expected commercial importance. Currently there are significant limitations in terms of the preparation of CB11- and B122- anions, which have so far prevented the widespread use of them. The goal of the first part of our project is to develop innovative and convenient methods for the selective synthesis of functionalized carborane and borane cage compounds. The community of inorganic and organic chemists as well as materials science experts will greatly profit from our research. As the second part of the project, we will carry out research in three different fields of applications.

本课题主要集中于研究和发展具有广阔应用前景的笼状物化学。含有CB11-和B122-核的硼笼状物阴离子是一类有机/无机杂化物，其独特的立体化学和电性质使得它们与传统的金属复合物及有机分子显著不同，另外，该类化合物非常稳定，并且毒性很低。最近的文献报道表明，它们在立体选择性合成、荧光磷光应用、材料科学和生物化学等领域贡献重大，因而也具有一定的经济意义。 目前由于CB11-和B122-离子的合成技术还受到很大限制，导致它们的应用还不是特别广泛。本课题第一部分的目标就是发展新型及简易的方法用来选择性合成功能化的碳硼烷和硼烷类笼状分子。无机和有机化学及材料科学将极大地受益于我们的研究。对于第二部分，我们将对此类化合物在三个不同领域的应用进行探索。

笼状硼烷阴离子CB11和B12是一类无机或有机的硼氢化分子，它们具有独特的立体以及电子性质，这使得其与普通的金属络合物以及有机分子都有着显著的区别。另外，它们十分稳定且低毒，在配体设计，超分子化学，药物化学，荧光分子以及材料科学都有应用。我们的工作致力于为硼烷阴离子的选择性官能团化发展新的方法学。我们主要是用过渡金属催化的策略实现B-H键活化。本报告将阐述第一次将CB11和B12转化为以前从没得到过的产物。研究内容包括B-H键活化过程的基础研究以及创新且方便的催化条件。这些新和成的化合物包含了从B-H键直接转化过来的B-C，B-O和B-卤键。关于应用，我们报道了其抗菌性与荧光性质。有机、无机以及材料科学的专家都将从这些成果中受益。