ADF/cofilin去磷酸化与肝细胞极性重建
基本信息
结项摘要
体外肝细胞极性重建是生物人工肝研究的重要组成。体外分离肝细胞因极性丧失而导致无功能。细胞极性建立机制的探索可用于指导体外肝细胞极性重建。目前认为：肌动蛋白解聚因子ADF/cofilin磷酸化引起的细胞骨架重塑是细胞极性建立的关键环节。蛋白磷酸化与去磷酸化是酶动力学紧密相关的两个过程。本课题通过基于ADF/cofilin的蛋白磷酸酶SSH1L的序贯性实验- - SSH1L活化与肝细胞极性建立关系、S
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数据更新时间：2023-05-31
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