甲基苯丙胺成瘾者冲动行为及经颅磁刺激干预研究

Methamphetamine addiction is often associated with binge drug intake and impulsive behaviors; the impulsivity significantly contributes to relapse, and acts as a risk factor for social security. Current addiction management approaches are limited in reducing impulsivity. The present project aims to track the dynamic changes of craving and impulsive behavior during a two year withdrawal period. The EEG measurement is combined to reveal the underlying neural mechanisms. In addition, the study combines transcranial magnetic stimulation intervention to see potential effects on craving as well as impulsivity. The project will provide rationales for application of transcranial magnetic stimulation intervention in management of methamphetamine addicts, especially in reducing their impulsive behaviors.

甲基苯丙胺成瘾常伴随冲动性用药和冲动行为；其冲动行为是导致戒断后复吸的高危因素，也直接影响了社会安定，而现有治疗手段尚无法对成瘾者冲动性进行针对性康复。本项目将在横断面与纵向(两年期)同时追踪大样本甲基苯丙胺成瘾者戒断后渴求度与冲动性的动态变化，结合脑电记录显示其生理机制，并于不同时间点结合经颅磁刺激干预观察效果。本项目将为经颅磁刺激干预应用于甲基苯丙胺成瘾者戒毒管理，及抑制其冲动行为提供新的措施。

本项目聚焦甲基苯丙胺成瘾者冲动的神经心理机制，采用多层次认知行为任务结合，解析了不同戒断期甲基苯丙胺成瘾者冲动行为的时间机制，基于人和成瘾动物的研究则揭示了运动皮层深入介入了冲动行为。研究人员基于非侵入式神经调控技术针对甲基苯丙胺成瘾者冲动性进行调控，制定了若干干预策略，并揭示了额叶-纹状体通路在此过程中的重要作用，并将相关发现在成瘾患者中进行验证和转化应用。