HIM82/70对呼吸爆发心脏－NADPH氧化酶的调节
基本信息
结项摘要
It was found that McAb HIM70 has down-regulation effect on NADPH oxidases, which were the "heart" of production of ROS in Np. The results shown that the expressiones of P47 phox, P67 phox and Rac2 and the activation of NADPH oxidase could be down-regulatated by this McAb. We have demonstrated that this effection of McAb HIM70 on NADPH oxidase may have relation with activities of PKC, PTK and PI3K pathways reduced by McAb HIM70. And the results futher support that CD15, the differentiation antigen of HIM70 could regulate the activation of NADPH oxidase. All of these results provide academic foundation and practical tool for the prevention and cure of most inflammation aroused by ROS and ischemia reperfusion damage.
本题通过单抗HIM82/70对中性粒细胞NADPH氧化酶重要组分Rac蛋白从胞浆中转位到质膜参与NADPH氧化酶活化(组装)及上游信息途径调节的研究阐明该单抗降调节中性粒细胞呼吸爆发幕怼
项目摘要
项目成果
{{i.achievement_title}}
{{i.achievement_title}}
暂无此项成果
数据更新时间：2023-05-31
其他相关文献
山核桃赤霉素氧化酶基因CcGA3ox 的克隆和功能分析
山核桃赤霉素氧化酶基因CcGA3ox 的克隆和功能分析
盐度对虹鳟和硬头鳟幼鱼消化酶和抗氧化酶活性的比较研究
盐度对虹鳟和硬头鳟幼鱼消化酶和抗氧化酶活性的比较研究
护阳养坤方通过JNK-p38/P65-NF-κB通路对卵巢颗粒细胞的保护机制研究
护阳养坤方通过JNK-p38/P65-NF-κB通路对卵巢颗粒细胞的保护机制研究
急性高温胁迫对虹鳟和硬头鳟幼鱼抗氧化酶活性的影响
急性高温胁迫对虹鳟和硬头鳟幼鱼抗氧化酶活性的影响
Ordinal space projection learning via neighbor classes representation
Ordinal space projection learning via neighbor classes representation
法祥光的其他基金
相似国自然基金
粒细胞分化抗原单抗HIM82对Np呼吸爆发的调节作用
NADPH氧化酶源性活性氧对老年小鼠心脏重构的影响及机制
NF-κB和NADPH氧化酶相互调节介导脓毒症免疫状况转换的机制研究
马铃薯NADPH氧化酶Strboh基因调控块茎休眠解除的机制