杯芳烃及杯杂芳烃的超分子化学研究

22 (6 kinds) new calixarene or thiacalixarene derivatives were synthesized and characterized.Their supramolecular interaction with metal ions，some nucleotide and amino acid including molecular recognition,membrane transport,supramolecular catalysis and LB film self-assembly were studied. The calixarene and their derivatives have a bigger recognition abilities towards alkali metal than transitional metal. In contrary, the thiacalixarene and their derivatives exhibit good recognition abilities towards transitional metal.These studies propose potential applications of these derivatives in environment protection and medical treatment. The uridine-containing calixarene derivatives have a special recognition ability towards ATP. Studies show their interaction is based on the hydrogen bond between uridine and adenine. The calixarene derivative with the chiral group can chirally recognize threonine and has the potential to be used in separating enantiomers of amino acids. The introduction of calixarene into polymer break a new path to develop new functional materials containing calixarene.

合成多种杯芳烃、杯杂芳烃衍生物，将核苷酸碱基引入杯芳烃或杯杂芳烃母体，作为分子识别因子，研究这类新型受体对核苷酸、氨基酸等不同底物的分子识别、分子组接及液膜传输作用；进二研究对核苷酸水解的超分子催化机理，和对多肽及DNA定位切割，对药物分子的霞鞍邢虼荩岸杂卸窘鹗衾胱拥姆掷搿⒋倥抛饔玫目赡苄浴?...