GLP-2突变体和防御素5多基因表达质粒转染治疗肠道损害的实验研究
基本信息
结项摘要
肠道损害（包括肠上皮损伤和肠粘膜免疫功能抑制）十分常见，尤其在放射损伤或腹部肿瘤放疗时更为突出而严重，目前尚无有效治疗措施。本课题在我们原有工作基础上，创新性地提出解决肠道损害问题，应既能促进肠上皮修复，又能增强粘膜免疫的"双管齐下"策略，优选特异性促肠上皮增殖的胰高血糖素样肽2（GLP-2）和能抗细菌、抗真菌并能中和毒素的防御素5 作为实现这一思路的活性生物分子。首先将GLP-2进行定点突变，防
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数据更新时间：2023-05-31
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