pAPC对ALD-DNA的模式识别及应答：ALD-DNA诱导SLE的可能机制
基本信息
结项摘要
我们先前的实验首次以活化淋巴细胞来源的DNA（ALD-DNA）在非特定遗传背景小鼠中诱生抗dsDNA抗体及诱发SLE，并发现pAPC可能在其中扮演重要角色。为进一步明确pAPC在ALD-DNA诱生抗dsDNA抗体和SLE中的作用，本项目拟通过pAPC对ALD-DNA的摄取及其剂量依赖关系的研究，观察pAPC摄取ALD-DNA后对其主要表面分子表达的调节和分泌细胞因子的影响；研究pAPC对ALD-DNA的递呈及其在T细胞活化中的作用;建立抗dsDNA抗体体外诱生细胞模型，研究pAPC在ALD-DNA介导的B细胞活化及其产生抗dsDNA抗体中的作用，同时以siRNA技术研究模式识别受体TLR9在介导ALD-DNA活化pAPC进而诱导SLE中的作用及机制，为阐明ALD-DNA诱导SLE的细胞学基础及针对性的防治措施的研究奠定基础。
项目摘要
项目成果
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数据更新时间：2023-05-31
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