治疗股骨头坏死的中药缓释剂型（木豆叶水提物/CPPF/n-HA/不饱和聚酯酰胺复合物）研究

The incidence of ONFH has been found to increase obviously due to trauma, alcohol and hormone abuse.The key mechanism of ONFH is the blood circulatory disorder in the fem oral head; The decline of mechanical strength causes collapse of femoral head, which decides the disease development.If effective measures can be taken during the collapse period, the blood supply and mechanical strength can be improved, and the collapse can be prevented and bones can be repaired to maintain the normal function of hip joint.A lot of research has been done but so far it is still difficult to solve the two problems at the same time. Water-soluble extracts from Cajanus cajan Leaf functions to activate blood and dissolve stases, tonify kidney and strengthen bones, proving to be the effective drug in treating ONFH.This project aims to study that the material with high strength and high modules can completely degradate the bioartificial material in the bearing bone. Then, the influence of synthesis and cross linking of unsaturated polyester amide compound is further discussed. The preparing technique of artificial compound material can be further modified. Next, mix with Water-soluble extracts from Cajanus cajan Leaf to prepare a release system, which can gradually degradate the drug to release until to achieve the mechanical strength, thus improve the blood supply and develop the process of repairing.

由于创伤、酗酒和滥用激素等原因，骨科疑难病症- - 股骨头坏死的发病率明显增加。各种原因造成的股骨头内血液循环障碍是股骨头坏死的关键病机；力学强度下降导致股骨头塌陷是该病发展的重要转折。如果能在骨塌陷期采取有效措施，改善血供和重建股骨头的力学强度，可防止塌陷和促进骨修复，保存髋关节功能。骨科界对此做了很多研究，但目前还难以同时解决好这两个问题。木豆叶水提物有活血化瘀，补肾健骨作用，是治疗股骨头坏死的有效药物。本课题拟在前期研究高强度高模量可完全降解负重骨内固定人工复合生物材料的基础上，继续探讨复合材料基体不饱和聚酯酰胺的合成及交联参数对其力学及降解性能的影响；进而优化人工复合材料( C P P F / n - H A / 不饱和聚酯酰胺)制备技术；然后与木豆叶水提物复合制成一种缓释系统,随人工复合材料逐步降解药物持续释放达到早期重建力学强度,全程改善血供、促进修复的目的。

由于创伤、酗酒和滥用激素等原因，骨科疑难病症--股骨头坏死的发病率明显增加。各种原因造成的股骨头内血液循环障碍是股骨头坏死的关键病机；力学强度下降导致股骨头塌陷是该病发展的重要转折。如果能在骨塌陷期采取有效措施，改善血供和重建股骨头的力学强度，可防止塌陷和促进骨修复，保存髋关节功能。骨科界对此做了很多研究，但目前还难以同时解决好这两个问题。木豆叶水提物有活血化瘀，补肾健骨作用，是治疗股骨头坏死的有效药物。. 本课题主要研究制备具有高强度、高模量和可控降解吸收的中药缓释剂型，然后表征其物理力学、生物性实验及治疗效果评价，使该复合材料能够满足重建股骨头坏死区域的力学强度，促进血运修复和骨重建的要求。取得的重要研究成果有，本复合材料中药缓释剂强度合适，治疗效果明显，能将重建血运和力学重建良好地结合起来，从而达到股骨头坏死区域修复、保留自身股骨头的目的。具有明显的现实意义和应用前景。