口腔修复常用金属合金腐蚀产物激活Nrf2-ARE信号通路参与牙周局部炎症反应的机理研究

Gingival dyed with black colour, congestion and inflammation around metal alloy denture are used to find in common clinic. The occurrence of this phenomenon is closely related to the tissue inflammatory response caused by long-term corrosion of the metal prosthesis in the oral environment. However, the mechanisms by which the corrosion products of metal alloys lead to inflammation are not clear. Nrf2-ARE signaling pathway is one of the most important signaling pathways of oxidative stress. It is found to be involved in inflammatory reaction in recent years’ research. Therefore, in this study, the corrosion of dental alloys commonly used by accelerated potentiodynamic polarization simulation was investigated and the corrosion products produced by them were applied to gingival fibroblasts Activation of Nrf2-ARE signaling pathway to inhibit the molecular mechanism of inflammatory response, and thus provide a theoretical basis for the solution and prevention of gingival inflammation caused by the corrosion products of commonly used alloy materials.

临床中常见金属合金制作的义齿周围出现牙龈黑线、红肿充血等炎症现象。这种现象的产生与金属修复体长期在口腔环境下生成腐蚀产物导致的组织炎症反应有一定的联系。然而金属合金的腐蚀产物导致炎症的机制尚不明确，Nrf2-ARE信号通路是今为止发现的抗氧化应激机制中最重要的通路之一，近年来发现其也参与了炎症反应。因此本研究主要探索通过恒电位极化法模拟加速常用的口腔修复合金材料的腐蚀，并对其所产生的腐蚀产物作用于牙龈成纤维细胞激活Nrf2-ARE信号通路抑制炎症反应的分子机制，从而为解决和预防常用合金材料的腐蚀产物造成牙龈炎症反应提供一定的理论依据。

临床中常见金属合金制作的义齿周围出现牙龈黑线、红肿充血等炎症现象。这种现象的产生与金属修复体长期在口腔环境下生成腐蚀产物导致的组织炎症反应有一定的联系。然而金属合金的腐蚀产物导致炎症的机制尚不明确，Nrf2-ARE信号通路是今为止发现的抗氧化应激机制中最重要的通路之一，近年来发现其也参与了炎症反应。因此本研究主要探索通过恒电位极化法模拟加速常用的口腔修复合金材料的腐蚀，并对其所产生的腐蚀产物作用于牙龈成纤维细胞激活Nrf2-ARE信号通路抑制炎症反应的分子机制进行了研究。从而为解决和预防常用合金材料的腐蚀产物造成牙龈炎症反应提供一定的理论参考依据。 本项目执行期间，发表第一标注本项目SCI论文1篇；中文论著1篇；第二标注中文论著1篇；第三标注SCI论文1篇；培养硕士研究生1名、博士研究生1名。已完成计划任务书的各项考核指标。