PAHs对儿童智力发育的影响及影响机制研究

Polycyclic aromatic hydrocarbons（PAHs）are one of the most widespread environmental contaminants. Although the studies about neurobehavioral developmental toxicity and its mechanism extend nearly ten years, there are some scattered relative references. The convinced models of dose-response relationship and dose-effect relationship between the PAHs and neurobehavioral developmental toxicity have not been established. Moreover, the mechanism of neurobehavioral developmental toxicity remains unclear. Supported by NSFC (81041077), our experiments prove that exposure to PAHs leads to neurobehavioral developmental toxicity by inhibiting the release of amino acid neurotransmitters from synapses. According to the studies in China and abroad, based on the work done before, combining the population survey and animal experiments, we will detect the impairments of intelligence and behavior,the damage of cellular and subcellular structure, as well as the release of neurotransmitters. Thus, models of dose-response relationship and dose-effect relationship between the PAHs and toxicity of intellectual and behavioral development will be established, and the molecular mechanism of PAHs induced behavioral development will be clarified, and will provide evidence for preventing the harm of intelligence development caused by PAHs.

多环芳烃类（PAHs）是极重要的环境污染物，国内外对于其神经行为发育毒性及其机制的研究已经持续了近十年，但相关的研究资料极为零散，迄今国内外也未能建立可信的剂量-反应与剂量-效应关系模型，对其神经行为发育的机制研究也不清楚。课题组在NSFC（81041077）资助下研究证实了PAHs具有一定的神经行为发育毒性，研究提示PAHs的神经行为发育毒性可能是由氨基酸类神经递质突触释放障碍造成的。 本项目将根据目前国内外相关研究的情况，在前期研究的基础上联合运用人群调查与动物实验方法，应用行为学、生化及细胞与分子生物学等手段，从PAHs引起的智力与行为能力的改变；细胞与亚细胞结构损伤；重点是神经递质的释放障碍等不同层面进行研究，构建PAHs智力行为发育毒性的剂量-反应与剂量-效应关系模型，阐明PAHs的神经行为发育毒性的分子机制，为预防其智力行为发育危害提供科学依据。

多环芳烃类（PAHs）是极重要的环境污染物，国内外对于其神经行为发育毒性及其机制的研究已经持续了近二十年，但相关的研究资料极为零散，对其神经行为发育的机制研究也不清楚。课题组在前期研究中证实了PAHs具有一定的神经行为发育毒性，研究提示PAHs的神经行为发育毒性可能是由氨基酸类神经递质突触释放障碍造成的。. 本项目根据目前国内外相关研究的情况，在前期研究的基础上联合运用人群调查与动物实验等方法，应用行为学、生化及细胞与分子生物学等手段研究PAHs引起的智力与行为能力的改变；细胞与亚细胞结构损伤；重点是从神经递质的释放障碍等不同层面进行研究，阐明了PAHs的神经行为发育毒性的主要分子机制，为预防其智力行为发育危害提供了科学依据。