基因与环境对创造性发展及其大脑结构与功能的影响

To cultivate or improve individual creative abilities is greatly influenced by genetic and environment factors, therefore, investigating the mechanisms of these influences on creativity development and even brain maturation in adolescents is helpful to the better improvement of their creative abilities. Based on these backgrounds, this project will go and continue the construction of a multimode neuroimaging database concerning creativity of about 1,200 adolescents, extending from brain and behavior data to gen data. Based on the database, this project plan to conduct the following researches: (1) to reveal the genetic bases of creativity, utilizing genome-wide association study (GWAS), polygenic analysis and candidate gene research in exploring the mechanism of genetic influences on creativity development, and on critical brain structure and function. (2) To systematically explore the influences of internal and external environment factors (such as family and school context, personality and working memory ability, etc.) on creativity development and brain maturation. (3) To reveal the interactive mechanism of genetic and environmental influences on creativity development and brain maturation by longitudinal investigation on the developmental database concerning creativity and fMRI neuroimaging changes. (4) To show effective ways of improving adolescent’s creative abilities and related brain plasticity by using trans-cranial direct current stimulation (tDCS) method. By revealing the genetic and environmental bases of creativity development and critical brain structure and function changes in adolescents, this project would further establish helpful creativity evaluation measures based on gen, brain and behavior researches, which can provide scientific guidance for cultivating innovational individuals.

遗传和环境是影响个体创造性发展的重要因素，探明基因与环境对青少年创造性发展及其大脑发育的作用机制，有利于更好地培养和提升个体的创新能力。基于此，本课题将在前期基础上，进一步建立青少年创造性多模态数据库（约1200人的基因-脑-行为），1）通过全基因组关联分析，多基因分析以及候选基因法探讨基因对创造性发展以及关键大脑结构与功能特征的作用机制，揭示创造性的遗传基础；2）系统探讨个体内外环境因素（如家庭和学校环境，人格以及工作记忆等）对创造性发展以及相应大脑发育的影响；3）通过纵向跟踪，建立创造性和脑影像的动态发展数据，揭示遗传和环境对创造性及其大脑发育的交互作用机制；4）通过神经刺激技术（tDCS），探讨提升青少年创造性的有效途径与大脑可塑性机制。本课题将深入揭示青少年创造性发展及其关键大脑结构与功能特征的遗传和环境基础，建立基于基因-脑-行为的创造性辅助评估方法，为创新人才培养提供科学依据。

遗传和环境是影响个体创造性发展的重要因素，探明基因与环境对青少年创造性发展及其大脑发育的作用机制，有利于更好地培养和提升个体的创新能力。基于此，本课题在前期基础上，进一步扩建了青少年创造性多模态数据库（截止目前共采集了约1200人的脑-行为-环境数据），基于该数据库开展了以下工作：1）通过全基因组关联分析，多基因分析以及候选基因法探讨基因对创造性发展以及关键大脑结构与功能特征的作用机制，揭示了创造性的遗传基础；2）系统探讨了个体内外环境因素（如家庭和学校环境，人格以及工作记忆等）对创造性发展以及相应大脑发育的影响；3）通过纵向追踪，采集了创造性和脑影像的动态发展数据，揭示遗传和环境对创造性及其大脑发育的交互作用机制；4）通过神经刺激技术（tDCS），探讨了青少年创造性提升的有效途径与大脑可塑性机制。总之，本课题在前期工作的基础上进一步深入揭示了青少年创造性发展及其关键大脑结构与功能特征的遗传和环境基础，初步建立了基于基因-脑-行为的创造性辅助评估方法，为创新人才的培养与提升提供了科学依据。