发作性睡病与中医体质关系的初步研究

While sleep quality is an important factor effecting people's wellness, Narcolepsy is a rare and complicated sleep disorder disease, clinically characterized by irresistibly excessive sleepiness, cataplexy, sleep paralyse and sleeping hallucination. It would be very unique to explore narcolepsy from the point of traditional Chinese medical science. By using the case only study method, this research is developing alarge sample study with narcolepsy patients as investigating targets. Based on the patient physiques, this study will investigate symptoms clinically, exam the gene HLA, analyze the characteristics of narcolepsy against the patient physique as well as the correlation between narcolepsy located gene HLA and physique in order to provide objective foundation to stereotype narcolepsy clinically.

睡眠是影响人群健康的重要因素，发作性睡病(Narcolepsy)以发作性不可抗拒的嗜睡、猝倒症、睡瘫症与入睡性幻觉为主要临床特点，属于少见病、疑难病。中医探讨本病有独特的科学应用价值。本研究采取case only的方法，对较大样本人群开展case only study，按标准化体质分型，将研究对象分为不同的体质类型，测量与分析病人的临床指征、实验室检查及易感基因（HLA），分析比较不同体质类型的睡病患者特点，及不同类型体质与其HLA易感基因的特点，深入探讨发病机制，为指导临床提供依据。

本项目通过在发作性睡病患者中的临床观察和分子生物学实验的一系列研究，主要发现点包括：1、肝郁、脾虚湿困是发作性睡病的主要证候；2、发作性睡病的主要病机是风痰内动，扰乱神明、经络；本病日久生变，或肝气郁结，抑郁健忘，或肝气上逆，急躁易怒，或脾虚湿盛，肥胖乏力。3、早发型睡病猝倒多见，症状多从阳化；晚发型睡病睡瘫多见，多伴有肝气郁结。4、中药醒神通窍汤治疗发作性睡病可能通过作用于下丘脑分泌素相关分子通路发挥作用。