手性功能化共价有机框架材料

As a new type of porous organic material, crystalline covalent organic frameworks (COFs) have been receiving wide interests since their discovery in Science in 2005. Functionalization has been the bottleneck of the development of COF materials. In this project, several novel chiral-functionalized COF materials will be constructed by using the chiral organic molecules as the functional building units through the “bottom-up” strategy. The synthesized chirality-functionalized COF materials will be applied in catalyzing the heterogeneous asymmetric reactions. The catalytic performance of these COF materials and their recycle use will be examined in several typical asymmetric transformations. This project takes advantage of the designable and controllable pore structure of COF materials, combines the regular pore structures and chiral organic molecules, and is expected to provide new approaches to the construction of functionalized COFs.

作为一种新型的有机多孔材料，晶型共价有机框架材料（Covalent Organic Frameworks，COFs）自2005年在Science上被首次报道以来引起了广泛关注。功能化是目前COFs材料发展的主要瓶颈。本项目拟采用自下而上的构筑策略，以手性有机小分子为功能化构筑基元，通过共价键的联结方式，构建一系列结构新颖的手性功能化COFs材料。然后将制备的手性功能化COFs材料应用于催化多相不对称反应，并实现其循环使用。本项目利用COFs材料可设计、可调控的结构特点，将有序孔道与手性功能有机小分子相结合，发挥了COFs材料框架结构与孔道结构的双重优势，将为功能化COFs材料的发展提供新思路和新途径。

构建手性功能化的COFs材料是共价有机框架材料领域的一个巨大挑战。本项目拟采用自下而上的构筑策略，以手性有机小分子为功能化构筑基元，通过共价键的联结方式，构建一系列结构新颖的手性功能化COFs材料。然后将制备的手性功能化COFs材料应用于催化多相不对称反应，并实现其循环使用。在三年的项目实施期间，本项目顺利完成了申请书所提交的研究计划，实现了直接从手性前体出发构筑手性功能化COFs材料及其催化应用，为手性COFs材料的设计合成及应用提供了新思路。在J. Am. Chem. Soc. (1), Chem. Commun. (2)刊物上发表标注本基金项目资助的论文3篇，申请中国发明专利4项，获得授权发明专利2项。同时，本项目取得的成果还包括待发表的论文1篇。