弥散加权不相干/偏相干运动成像对心肌复杂微循环特征的评估

The traditional Intravoxel Incoherent Motion (IVIM) which based on the distribution of blood vessels in single voxels and satisfies all the same distribution characteristics is able to obtain the physiological information of tissue perfusion without contrast agent. A new model voxel in partial coherent and incoherent motion (Intravoxel Partially Coherent and Incoherent Motion, IVPCIM) takes into account the bulk isotropic distribution of arterioles and venues and capillaries were in anisotropic distribution due to the anisotropic distribution characteristics of the myocardium capillary. The purpose of this study was to investigate the value of IVPCIM myocardial perfusion model in ischemic cardiomyopathy by random animal experiments and compared with the traditional method of non-contrast enhanced contrast research, to obtain different states of myocardial ischemia (infarction / salvage / ischemia / reperfusion injury) microcirculation perfusion parameters of myocardial disease (perfusion fraction f value, pseudo diffusion coefficient D* value, small vascular volume fraction fav and capillary volume fraction of fc value), to evaluate the threshold of myocardial microcirculation and the evolution of myocardium in different myocardial lesions, and verify the IVPCIM model can more accurately and comprehensively reflect the physiological characteristics of complex microcirculatory network perfusion in different states of myocardium. The conclusion of the project are of great significance to the diagnosis of ischemic myocardium disease, the treatment decision and prognosis.

传统双指数模型（IVIM）基于单个体素内的血管分布满足各项同性分布的特性，无需对比剂的情况下，能够直观地获得组织灌注的生理信息。但心肌组织中毛细血管服从各向异性分布的特点，新的体素内偏相干与不相干运动(IVPCIM)模型则兼顾了体素内各向同性分布的小动脉和小静脉以及各向异性分布的毛细血管。本研究通过随机动物实验研究设计，对IVPCIM在心肌缺血模型中的价值进行深入研究，并与传统方法非对比增强进行对比研究，尝试获得不同状态心肌缺血（梗死/顿抑/缺血/再灌注损伤）病变心肌的微循环灌注参数（小血管容积分数fav，小血管伪扩散系数D*，毛细血管容积分数fc，毛细血管内血液流速u0），评估不同缺血性心肌病变微循环障碍及心肌缺血的演变情况，验证IVPCIM模型能更准确且全面地反映不同状态心肌组织复杂微循环网络灌注的生理特征。研究成果对于缺血性心脏病诊断、治疗方案的临床决策具有重要意义。

传统双指数模型（IVIM）基于单个体素内的血管分布满足各项同性分布的特性，无需对比剂的情况下，能够直观地获得组织灌注的生理信息。但心肌组织中毛细血管服从各向异性分布的特点，新的体素内偏相干与不相干运动(IVPCIM)模型则兼顾了体素内各向同性分布的小动脉和小静脉以及各向异性分布的毛细血管。本研究通过随机动物实验研究设计，对IVPCIM在心肌缺血模型中的价值进行深入研究，并与传统方法非对比增强进行对比研究，尝试获得不同状态心肌缺血（梗死/顿抑/缺血/再灌注损伤）病变心肌的微循环灌注参数（小血管容积分数fav，小血管伪扩散系数D*，毛细血管容积分数fc，毛细血管内血液流速u0），评估不同缺血性心肌病变微循环障碍及心肌缺血的演变情况，验证IVPCIM模型能更准确且全面地反映不同状态心肌组织复杂微循环网络灌注的生理特征。研究成果对于缺血性心脏病诊断、治疗方案的临床决策具有重要意义。