“N-F” / [Cu] / LA催化体系内sp3 C-H键活化构筑C-O键及其催化机理研究

Focusing on sp3 hybridized C-H bond, a new type, high efficiency, high selectivity "N -" F/Cu/LA catalytic system was designed to study the new method of C-O bond construction via sp3 hybridized C-H bond activation. Through the template reaction research, the influence of different varieties and amount of the catalyst composition was investigated, and the problems of catalytic system matching and catalytic selectivity were soluted. The catalytic system was applied to a variety of benzyl, allyl, (ortho)ether bond, (cyclo)alkane sp3 hybridized C-H bond activation reaction, to prepare a variety of organic compounds containing C-O bond which traditional methods are difficult to synthesis. The unique catalytic activity and catalytic mechanism of the catalytic system were studied, combined with quantum chemistry calculations and a large number of experimental verification, reasonably come to the sp3 hybridized C-H bond activation theory. The implementation of the project will enrich and develop the C-H bond activation method and regulation of organic synthesis, expand its application in organic synthesis, and provide a reference method for some selective organic synthesis reaction. Subject has good innovative, it has good theoretical research value and application prospect.

以sp3杂化C-H键为研究对象，设计新型、高效、高选择性的“N-F” / [Cu] / LA催化体系，研究该催化体系内通过sp3杂化C-H键的活化反应构建C-O键的新方法。通过模板反应研究，考察不同催化组合、催化剂种类、用量等反应条件对实验结果的影响，解决催化体系各组分的匹配性、催化选择性等问题，并将该催化体系应用于各种苄位、烯丙位、醚键邻位、(环)烷烃等sp3杂化C-H键的活化反应，制备各种传统方法较难合成的含C-O键的有机化合物。研究该催化体系独特的催化活性和催化机理，并结合量子化学计算和大量实验进行验证，得出合理的sp3杂化C-H键活化理论。课题的实施将丰富和发展C-H键活化新方法和可调控有机合成技术，拓展该催化体系在有机合成中的应用范畴，并为某些选择性有机合成反应提供一条可借鉴方法。课题具有很好的创新性，具有较好的理论研究价值和应用前景。

以sp3杂化C-H键为研究对象，设计新型、高效、高选择性的“N-F” / [Cu] / LA催化体系，研究该催化体系内通过sp3杂化C-H键的活化反应构建C-O键的新方法。通过模板反应研究，考察不同催化组合、催化剂种类、用量等反应条件对实验结果的影响，解决催化体系各组分的匹配性、催化选择性等问题，并将该催化体系应用于各种苄位、烯丙位、醚键邻位、(环)烷烃等sp3杂化C-H键的活化反应，制备各种传统方法较难合成的含C-O键的有机化合物。研究该催化体系独特的催化活性和催化机理，并结合量子化学计算和大量实验进行验证，得出合理的sp3杂化C-H键活化理论。课题的实施将丰富和发展C-H键活化新方法和可调控有机合成技术，拓展该催化体系在有机合成中的应用范畴，并为某些选择性有机合成反应提供一条可借鉴方法。课题具有很好的创新性，具有较好的理论研究价值和应用前景。