含金属离子键合中心的手性荧光传感器的设计、合成及其在水溶液中对手性异构体的选择性识别研究

The project intends to design and synthesize the fluorescent ligands containing chiral center, and then make them react with transition metal ions (such as Cu2+, Fe3+, etc.) to get the clap or ring type fluorescent sensors. These metal complex sensors bear metal ion bonding center and fine pre-organization structure, which have strong bonding ability toward different configurations of the substrate in water (or containing water) solution. Then the project tries to study the fluorescence sensing properties of chiral smetal complex ensors which toward the common chiral substrate in environment or biology under an aqueous solution or physiological pH conditions. The project might develop a new approach in rapidly and acutely detect, monitor and trace analysis of common important compounds in a biologically or pharmaceutically aqueous solution or physiological pH conditions. It not only has a great significance and potential practical application prospects, but also could develop the theory of molecular recognition and supramolecular chemistry.

本项目拟设计并合成含手性中心的荧光配体，再使之与过渡金属离子（如Cu2+,Fe3+等）配位得到钳型或环型的金属-配体络合物荧光传感器，这类含金属离子键合中心的传感器具有能在水（或含水）溶液中优良的组织结构和对不同构型的底物的键合能力。研究这类含金属离子键合中心的手性荧光传感器在水（或含水）溶液中或生理pH条件下对环境、生物学上等常见不同构型手性底物的选择性识别和荧光传感性能。对开发作为在水（或含水）溶液中或生理pH条件下以对手性底物识别为基础的对生物学上、药学上和手性试剂等常见重要化合物的检测、监控以及微量分析等方面的快速灵敏的荧光化学传感器不仅具有重要意义和潜在的实际应用前景，而且能够丰富和发展以分子识别为基础的超分子化学理论。

设计并合成含荧光配体，再使之与过渡金属离子（如Cu2+,Fe3+等）配位得到钳型或环型的金属-配体络合物荧光传感器，这类含金属离子键合中心的传感器具有能在水（或含水）溶液中优良的组织结构和对不同构型的底物的键合能力。研究这类含金属离子键合中心的手性荧光传感器在水（或含水）溶液中或生理pH条件下对环境、生物学上等常见不同构型手性底物的选择性识别和荧光传感性能。对开发作为在水（或含水）溶液中或生理pH条件下以对手性底物识别为基础的对生物学上、药学上和手性试剂等常见重要化合物的检测、监控以及微量分析等方面的快速灵敏的荧光化学传感器不仅具有重要意义和潜在的实际应用前景，而且能够丰富和发展以分子识别为基础的超分子化学理论。