具有特殊药理活性黄酮木脂素及其衍生物的合成研究

Flavono-lignans is a small group of natural lignans. It shows strong biological activities, such as antihepatotoxic, antitumour. Therefore the total synthesis of flavono-lignans, the study on relationship between its structure and effectiveness have important academic significance and practical prospects. According to the suggestion of the committee of National Natural Science Foundation of China, we developed some researches of organic synthesis methodology, such as acid-catalyzed rearrangement of hydrobenzofuranoid neolignans to bicyclo[3,2,1]octanoid neolignans. Achievement of the work will contribute to organic synthesis methodology and medicines chemistry, and supply scientific basis for synthesis of effective medicines.

近期从天然界分离出的一种新黄酮木脂素5-MHC，它.可以杀死产生抗药性的细菌，即具有抑制受体产生抗药性的特殊药理活性，进行.该化合物及其类似物的全合成，以及药理实验和构效关系研究，无疑具有重要学术意义和实用前景。此项工作的完成，将对有机合成.方法Ъ耙┪锘в泄毕祝⒔铣捎行У囊种瓶挂┬砸┪锾峁?科学依据。.........