八棱丝瓜蛋白的结构与抗肿瘤活性研究

We purified the ribosome inactivating protein(RIPs) such as Luffaculins and Cucurmosin etc. What's more, we studied their physical and chemical properties, RNA N-glycosidase activity, potent toxin to the cells of tummy cancer、liver cancer、 leucocythemia and induction of cell death via apoptosis.We also studied the second structure of Luffaculins and grew the high quality single crystals of Cucurmosin. At the same time,we are researching the crystal structure. .Up to date,we have released eight pieces of papers,of which is SCI influence factor of 3.067. And we have also applied ten pieces of patent of china, of which the Luffaculins' has been examined for the second time and is almostly authorized.

从葫芦科植物八棱丝瓜等植物中提取新的核糖体失活蛋白，提纯并测定其理化性质，酶学性质，抗肿瘤活性，特别是对胃癌，肝癌等肿瘤细胞杀伤作用，及与肿瘤单抗连接制作免疫毒素。为研制新一代的抗肿瘤药物提供结构与功能的信息。