蛋白酶激活受体2在早期断奶仔猪胃肠黏膜屏障中的作用
基本信息
结项摘要
仔猪胃肠黏膜发育不全及损伤是导致"早期断奶应激综合征"的主要原因。蛋白酶激活受体2(PAR-2)通过调节黏膜屏障中的紧密连接(TJ)而对胃肠黏膜呈现很好的保护作用。本项目在本实验室已对猪新基因PAR-2成功克隆，并应用免疫组化法分析了PAR-2在仔猪体内分布的基础上，拟对仔猪断奶前后不同时期胃肠黏膜和TJ形态、结构变化进行观察，检测相关生理生化指标，并分别运用Real Time PCR和Western blotting检测PAR-2、TJ蛋白Occludin、Claudin-1、ZO-1 mRNA表达量以及蛋白含量的变化，同时检测肌注SLp-NH2(PAR-2激动剂)后上述各指标的变化，以探讨PAR-2及其激动剂对仔猪胃肠黏膜及其上皮细胞间TJ调控的分子机制，为最终开发防治"仔猪断奶应激综合征"的PAR-2激动剂或拮抗剂等新型药物，提高仔猪成活率提供理论和实验依据。
项目摘要
项目成果
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数据更新时间：2023-05-31
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