大位阻甲基丙烯酸酯类单体的高效不对称聚合制备手性螺旋高分子

To solve the problems of low activity and low stereoselectivity commonly encountered in previously reported asymmetric polymerizations, the current project will mainly focus on the development of enantiomeric chiral organometallic catalysts and organic catalysts for efficiently synthesizing optically active helical polymer via asymmetric polymerization by using bulky methacrylate. Influence of catalyst structure on polymerization behavior and polymer structure, as well as the polymerization mechanism will be investigated. The accomplishment of this project not only will afford highly efficient and stereoselective catalysts but also represent the first example of organocatalytic asymmetric polymerization, providing optically active, rigid one-handed helical polymers with high performance which have the potential applications in resolution/separation of enantioners, asymmetric catalysis and sensory functions.

本项目主要针对目前报道的不对称聚合存在着立构规整性控制不好、活性低等问题，以目标手性螺旋聚合物的结构为导向设计合成光学纯手性金属有机催化剂和有机催化剂，开展大位阻甲基丙烯酸酯类单体的不对称聚合，通过调控催化剂的电子和空间效应，研究催化剂结构与聚合行为和聚合物结构的关系，并在此基础上探索聚合反应的机理，发展高效、高立体选择性的不对称聚合催化剂，并实现手性有机化合物在催化不对称聚合方面的突破，制备高性能、高比旋光度的手性螺旋高分子材料。

本项目主要针对目前报道的不对称聚合存在着立构规整性控制不好、活性低等问题，以目标手性螺旋聚合物的结构为导向设计合成光学纯手性金属有机催化剂和有机催化剂，开展大位阻甲基丙烯酸酯类单体的不对称聚合，通过调控催化剂的电子和空间效应，研究催化剂结构与聚合行为和聚合物结构的关系，并在此基础上探索聚合反应的机理，发展高效、高立体选择性的不对称聚合催化剂，并实现手性有机化合物在催化不对称聚合方面的突破，制备高性能、高比旋光度的手性螺旋高分子材料。