耳蜗兴奋性损伤后神经营养素-3对神经元的保护作用研究
基本信息
结项摘要
耳蜗缺血、缺氧、声损伤等状态可造成传入神经元兴奋性损害，重者致不可逆神经性聋，是致听力残疾的重要原因，且尚无有效治疗手段。近年发现神经营养素3（NT-3）等神经营养因子对噪声和缺血引起的耳蜗神经元损伤有保护作用；申请者发现兴奋性神经元损伤后有2～4周的治疗机会，提示神经营养因子是很有前途的听神经病治疗药物。然而，要进入临床试验，尚须解决几个问题：①确定兴奋性损伤后再给药是否有效；②寻找简便、有效、
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数据更新时间：2023-05-31
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